PDF《输血新知》

输输输血 血 血新 新 新知 知知TTTr r ra a an n ns s sf f fu u us s si iio o on n n N N Ne e ew w ws s sl lle e et t tt t te e er r r

4 4 4t t th h h E E Ed d di i it t ti i io o on n n O O OC C CT T T / / /

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8 静脉注射免疫球蛋白 IVIG I.

V.- Globulin S 50ml 什麽是静脉注射免疫球蛋白? What is IVIG (Intravenous Immunoglobulin) -- I.V.-Globulin S 50ml? IVIG (I.V.- Globulin S)是由许多捐血者的血浆蠹崛《,每一批次的 IVIG,约由 10,000 个血浆单位加工处理而成.这些血浆是由本澳自愿、无偿捐血者捐献的血液所分离出来 的. I.V.-Globulin S 50ml 含有 2.5 克人类蛋白及

5 克麦芽糖(matose).IVIG 的活性成份是免 疫球蛋白 G , 即IgG . IgG 是正常人体对抗感染而产生的

5 种抗体之一 , 其余

4 种其它抗体是 IgM, IgA, IgD, and IgE. ,每类抗体在人体内均有不同的功能,而IgG 是长期存在於人体内以保 持人体对感染的控制. I.V. -Globulin S C is a product derived from human blood. The active ingredient is immunoglobulin, IgG. Each I.V.-Globulin S 50ml vial contains 2.5 g of IgG and

5 g of maltose. Each batch of I.V.-Globulin S is fractionated from approximately 10,000 blood donations by voluntary blood donors in Macao. IgG is one of the five classes of immunoglobulin normally produced by our immune system when exposed to foreign antigens. The other immunoglobulins are IgM, IgA, IgD, and IgE. Each one ot these classes of Igs are produced in different stages of the immune response and/or are engaged on specific roles in the humoral defense of the body. IgG is the longer lasting antibody. 适应症 Indications IVIG 的有效性维持

2 周至

3 个月,主要用於治疗以下三大类疾病 IVIG'

s effects last between

2 weeks to

3 months. It is mainly used as treatment in three major categories of illness: 1. 抗体水平低下的免疫缺陷疾病 Immune deficiencies featuring low antibody levels 2. 炎症及自体免疫疾病 Inflammatory and autoimmune diseases 3. 急性感染 Acute infections 输输输血 血 血新 新 新知 知知TTTr r ra a an n ns s sf f fu u us s si iio o on n n N N Ne e ew w ws s sl lle e et t tt t te e er r r

4 4 4t t th h h E E Ed d di i it t ti i io o on n n 澳门捐血中心Macao Blood Transfusion Service Tel:87914307,

87914386 E-Mail: [email protected] Http://www.ssm.gov.mo/cts/ Page

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5 美国药物及食品管理局(FDA)批准下列

6 种疾病可使用 IVIG The US Food and Drug Administration has approved the use of IVIG for the following

6 conditions: a. 先天性免疫力低下 Primary immunodeficiencies b. 原发性血小板减少性紫癜 Idiopathic thrombocytopenic purpura c. 川崎病 Kawasaki disease d. 大于

20 岁并接受了干细胞移植的病人 Hematopoietic stem cell transplantation in patients older than

20 years e. 慢性 B 淋巴细胞白血病 Chronic B-cell lymphocytic leukemia f. 儿童 HIV I 型感染 Pediatric HIV type

1 infection 其它适应症(Off-label Uses): - 慢性疲劳综合症 Chronic fatigue syndrome - 慢性脱髓鞘多发性神经炎 Chronic inflammatory demyelinating polyneuropathy (CIDP) - 难治性梭状芽孢杆菌结肠炎 Clostridium difficile colitis - 甲状腺眼病变 Graves'

ophthalmopathy - 肌肉萎缩症 Muscular Dystrophy - 包涵体肌炎 Inclusion body myositis - 癌性肌无力综合症 Lambert-Eaton syndrome - 红斑狼疮症 Lupus erythematosus - 多源性运动神经病变 Multifocal motor neuropathy - 多发性硬化症 Multiple sclerosis - 重症肌无力 Myasthenia gravis - 新生儿异体抗体免疫性血小板缺乏症 Neonatal alloimmune thrombocytopenia - Parvovirus B19 - 天疱疮 Pemphigus - 输血后紫癜症 Post-transfusion purpura - 肾移植后排斥 Renal transplant rejection - 习惯性流产 Spontaneous Abortion/Miscarriage - 僵硬人症候群 Stiff person syndrome - 危重(成年)病人伴严重的败血症和败血性休克 Severe sepsis and septic shock in critically ill adults - 中毒性表皮坏死症 Toxic epidermal necrolysis - 皮肌炎和多发性肌炎 Dermatomyositis and polymyositis - 格林-巴利综合症 Guillain-Barré syndrome - 慢性淋巴细胞性白血病及多发性骨髓瘤,以及各种罕有的免疫球蛋白合成障碍(如X-染色 体连锁无丙种球蛋白血症,低丙种球蛋白血症),可注射 IVIG 以维持适当的 IgG 以预防 感染. In chronic lymphocytic leukemia and multiple myeloma, as well as various rare deficiencies 输输输血 血 血新 新 新知 知知TTTr r ra a an n ns s sf f fu u us s si iio o on n n N N Ne e ew w ws s sl lle e et t tt t te e er r r