PDF《夏小乐【个人简介】》

【个人简介】 姓名夏小乐 性别男出生日期

1980 年10 月1日职称副教授 电话0510-85326829 传真0510-85918119 E-mail xiaolexia@jiangnan.

edu.cn 【学术简介】 目前主要从事酿造相关生物转化和微生物进化方面研究,注重生物计算与实验相结合. 学习和工作经历 2009.6-至今:江南大学,生物工程学院,副教授;

2013.8-2015.2:哈佛大学化学与化学生物学系,博士后;

2003.9-2009.7:华南理工大学,生物科学与工程学院,发酵工程专业,工学博士;

1998.9-2002.7:华南理工大学,食品与生物工程学院,生物工程专业,工学学士. 学术与社会兼职 美国微生物学会(ASM)会员,美国化学工程师协会(AIChE)会员. 江苏医用高分子材料工程技术研究中心副主任. 【研究领域】 1. 微生物和酶进化机制研究: 以醋酸杆菌和脂肪酶等代谢相关酶为目标,通过生物计算和代谢分析 其进化生理机制并进行定向改造. 2. 酿造生物转化研究:对催化介质化学和生物改性,结合工艺装备优化改善黄酒、液醋、特种油脂 等生物转化效率. 【主要论著】 (著作和论文) 近5年在发表论文

22 篇(SCI 收录

13 篇),完成专著

2 部. 其中代表性的著作和论文如下: 1.Xiaole Xia, Qingtong Zhou, Haojun Liang, Eugene Shakhnovich. Search of sequence space for potent aptamers using SELEX in silico. Journal of Chemical Theory and Computation. Revised 2. Xiaole Xia, Xiaoming Zhu, Hailing Yang, et al. Enhancement of rice vinegar production by modified semi-continuous culture based on analysis of enzymatic kinetic. Eur Food Res Technol,2015, 241(4):479-485. 3. Zhengliang Qi, Hailing Yang, Xiaole Xia, et al. Achieving high strength vinegar fermentation via regulating cellular growth status and aeration strategy. Process Biochemistry, 2014, 49:1063-1070. 4. Xiao-Le Xia, Shan Cong, Xiao-Rong Weng, Jin-Hua Chen, Jing-Fang Wang, and Kuo-Chen Chou. Molecular Simulation to Investigate the Cofactor Specificity for Pichia stipitis Xylose Reductase. Medicinal Chemistry, 2013, 10, 921-924. 5. Zhengliang Qi, Hailing Yang, Xiaole Xia, Yu Xin, Ling Zhang, Wu Wang, Xiaobin Yu. A protocol for optimization vinegar fermentation according to the ratio of oxygen consumption versus acid yield. Journal of Food Engneering, 2013. 116(2): 304-309. 6. Xiaole Xia, Jingfang Wang, Yu Xin , Ling Zhang and Wu Wang. Insight of Pseudomonas cepacia lipase enantioselectivity towards chiral 1-phenyl ethanol and its derivates. Journal of Food, Agriculture &

Environment 2012,

10 (3&

4): 202-206. 7. Xiaole Xia, Yong-Hua Wang, Bo Yang, Xiaoning Wang. Wheat germ lipase catalyzed kinetic resolution of secondary alcohols in non-aqueous media. Biotechnology Letter, 2009, 31(1):83-87. 8. Xiaole Xia, Chen Wang, Yong-Hua Wang, Bo Yang, Xiaoning Wang. Water activity dependence of lipases in non-aqueous biocatalysis;

Applied biochemistry and biotechnology. 2009, 159(3): 759-767. 9. Li changling, Yang Hailing, Xia Xiaole etal. High efficient treatment of citric acid effluent by Chlorella vulgaris and potential biomass utilization. Bioresource technology. 2012, 127: 248-5. 10. Yu Xin, Hailin Yang, Xiaole Xia, Ling Zhang, Chen Cheng, Guocui Mou, Jiebing Shi, Yunfei Han,Wu Wang. Affinity purification of a cholesterol oxidase expressed in Escherichia coli, Journal of Chromatography B, 2011, 4:85-90. 11. Yu Xin, Hailin Yang, Xiaole Xiao, Ling Zhang, Yuran Zhang, Yanjun Tong, Yi Chen, Wu Wang. Affinity purification of urinary trypsin inhibitor from human urine. J. Sep. Sci. 2012, 35, 1C6. 12. 王武,唐蕾,夏小乐 等 生物技术基础 ,科学出版社 十二五 规划入选双语教材,2012.9 授权发明专利如下: 1. 夏小乐;