PDF《张瑞雪》

基本信息区 姓名 张瑞雪 Rui Xue (Vicki) Zhang 性别 女 出生 年月

1983 年01 月 所在单 位 生命学院 职称 副教授 Assoc.

Prof. 学习经 历2016 年, 制药科学专业,博士(Ph.D.),加拿大多伦多大学

2009 年, 医学科学专业,硕士(M.Sc.),加拿大麦克马斯特大学

2007 年, 分子生物专业,学士(B.Sc.),加拿大麦克马斯特大学 工作经 历2018 年至今,任西北工业大学生命学院副教授

2016 -2017 年,多伦多大学药学系博士后 通联方 式 电子

邮箱:[email protected] 教师主页:中文版 English Version 扩展信息区 研究方 向 基于脂质和聚合物的递药系统,研究: 新型协同联合用药纳米递药系统的设计、表征以及评价 临床前纳米药物在体内的宏观与微观代谢动力和生物分布 口服药物制剂的设计及应用 主讲课 程Will Come Up Soon! 请关注 ? 科研项 目1) 主持中央高校基本科研业务费资助项目 (G2018KY0302), "脂质聚合物纳米递药载 体和生物系统相互作用的研究",2018 C 2020. 2) 参与加拿大国家 Canadian Institutes of Health Research (CIHR) (487924), "Targeted Nanoparticle Carrier for Drug Combination Therapy of Breast Cancer",2009 C 2017. 3) 参与加拿大国家 Canadian Breast Cancer Foundation (CBCF) C Ontario Region (487673), "Targeted and Enhanced Chemotherapy of Lung and Brain Metastases of Triple Negative Breast Cancer" ,2009 C 2017. 学术成 就#并列第一作者;

* 通讯作者;

?高被引论文

2018 年oR.X. Zhang, J. Li, T. Zhang, M.A. Amini, C. He, B. Lu, T. Ahmed, H.Y. Lip, A.M. Rauth, X.Y. Wu* , Importance of Integrating Nanotechnology with Pharmacology and Physiology for Innovative Drug Delivery and Therapy C An Illustration with Firsthand Examples, Acta. Pharmacol. Sin., 2018.39: 825-844. (影响因子: 3.562)

2017 年oR.X. Zhang# , L.Y. Li# , J. Li, Z. Xu, A.Z. Abbasi, L. Lin, M.A. Amini, W. Weng, Y. Sun, A.M. Rauth, X.Y. Wu* , Coordinating Bio-Interaction and Bio-Reaction of a Nanocarrier Material and an Anticancer Drug to Overcome Membrane Rigidity and Target Mitochondria in Multidrug-Resistant Cancer Cells,Adv. Funct. Mater., 2017, 27(39): 1700804-1700816. (影响因子:13.325) o R.X. Zhang, T. Zhang, K. Chen, J. Cheng, P. Lai, A.M. Rauth, K.S. Pang, X.Y. Wu* , Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-Bearing Mice,J. Vis. Exp., 2017, 128(e56159): 1-13. (影响因子:1.184) o R.X. Zhang, T. Ahmed, L.Y. Li, J. Li, A.Z. Abbasi, X.Y. Wu* , Design of Nanocarriers for Nanoscale Drug Delivery to Enhance Cancer Treatment Using Hybrid Polymer and Lipid Building Blocks, Nanoscale, 2017, 9: 1334-1355. (影响因子:7.233)?

2016 年oR.X. Zhang, P. Cai, T. Zhang, K. Chen, J. Li, J. Cheng, K.S. Pang, H.A. Adissu, A. M. Rauth, X.Y. Wu* , Polymer-Lipid Hybrid Nanoparticles Synchronize Pharmacokinetics of Co-encapsulated Doxorubicin-Mitomycin C and Enable Their Spatiotemporal Co-delivery and Local Bioavailability in Breast Tumor, Nanomedicine-Nanotechnol., 2016, 12: 1279-1290. (影响因子:6.5) o R.X. Zhang # , H.L.Wong# , H.Y. Xue, J.Y. Eoh, X.Y. Wu* , Nanomedicine of Synergistic Drug Combinations for Cancer Therapy - Strategies and Perspectives, J. Control. Release., 2016, 240: 489-503. (影响因子:7.877)

2016 年之前 o A. J. Shuhendler# , P. Prasad# , R. X. Zhang# , M.A. Amini, M. Sun, P.P. Liu, R.G. Bristow, A.M. Rauth, X.Y. Wu* , Synergistic Nanoparticulate Drug Combination Overcomes Multidrug Resistance, Increases Efficacy, and Reduced Cardiotoxicity in a Non-immunocompromised Breast Tumor Model, Mol. Pharmaceut., 2014, 11: 2659-2674. (影响因子:4.556) o J.D. Huizinga* , J-H Chen, Y.F. Zhu, A. Pawelka, R.J. McGinn, B. L. Bardakjian, S.P. Parsons, W. A. Kunze, R.Y. Wu, P. Bercik, A. Khoshdel, S. Chen, S. Yin, Q. Zhang, Y. Yu, Q. Gao, K. Li, X.Hu, N. Zarate, P. Collins, M. Pistilli, J. Ma, R.X. Zhang, D. Chen, The Origin of Segmentation Motor Activity in the Intestine, Nat. Commun., 2014, 5: 3326-3337. (影响因子:12.353) o R.X. Zhang, X.Y. Wang, D. Chen, J.D. Huizinga* , Role of Interstitial Cells of Cajal in the Generation and Modulation of Motor Activity Induced by Cholinergic Neurotransmission in the Stomach, Neurogastroent. Motil., 2011, 23: e356-371. (影响因 子:3.842) 获奖和荣誉