PDF《Preparation of Curcumin Solid》

姜黄素;

溶出度,稳定性;

缓释;

肿瘤抑制;

药物动 力学 Abstract Preparation of Curcumin Solid Lipid Nanoparticles and Studies of the Anti-Cancer Effect in vitro and Pharmacokinetics in Rats after Introvenous Administration Jiabei Sun Supervisor: Dr. Zheng Ying Institute of Chinese Medical Sciences Solid lipid nanoparticles (SLN) is a new colloid drug delivery system, which simutanously combines the advantages of both polymer nanoparticles system and liposome system and avoids the disadvantages of them. The solid matrix of polymer nanoparticles could make the SLN system more stable. While the lipid carrier makes SLN physical tolerable, bio-compatible and less toxcic. SLN could improve the solubility of lipophlic compounds, protect drug from degradation or biotransformation and provide the sustained release of the drug. Curcumin is a polyphenol derived from Chinese herb Curcuma longa. It possesses diverse pharmacological activities, such as anti-oxidant, anti-inflammation and anti-cancer activities. Poor solubility and stability, rapid metabolism, biotransformation and systemic elimination attributed to the low bioavailability of curcumin and limits its clinical application. The purpose of this research is to encapsulate curcumin into SLN to improve its solubility and stability in aqueous system. Firstly, the parameters for preparation of SLN were optimized, including the concentration of lipid, surfactant, drug and lyophilized protectant. The morphology, physical stability and release profile of curcumin in the optimized formula of SLN were investigated. Subsequently, the anti-cancer effect of formulation was carried out on a human bre........