PDF《己唑醇 / 介孔 SiO2 缓释纳米球的制备及其性能》

林业工程学报, 2019,4(3):80-85 Journal of Forestry Engineering DOI:10.

13360 / j.issn.2096-1359.2019.03.012 收稿日期:2018-06-23 修回日期:2019-01-03 基金项目:江苏省自然科学基金(BK20130969);

江苏省生物质绿色燃料与化学品重点实验室开放课题(JSBGFC14015);

江苏省大学生实践 创新训练计划项目(20170298067). 作者简介:徐南方,女,研究方向为森林保护. 通信作者:徐鹏,男,副教授. E?mail: xupeng@ njfu.edu.cn 己唑醇 / 介孔 SiO2 缓释纳米球的制备及其性能 徐南方1 ,徐鹏2? ,岑昌丽2 ,陈难难2 ,邵伟2 ,唐进根1 (1.南京林业大学林学院,南京 210037;

2.南京林业大学化学工程学院,南京 210037) 摘要:基于 St?ber 方法, 制备出介孔 SiO2 纳米球(MSNs)和树枝状介孔 SiO2 纳米球(dMSNs),并以己唑醇(He) 为模型农药,通过物理吸附方法分别制备了己唑醇/ 介孔 SiO2 复合纳米球(He/ MSNs) 和己唑醇/ 树枝状介孔 SiO2 复合纳米球(He/ dMSNs). 采用透射电子显微镜(TEM)、傅里叶变换红外光谱仪(FT?IR)对制备的介孔纳米 球形貌和结构进行表征;

利用 Brunauer?Emmett?Teller (BET)气体吸附法对介孔二氧化硅纳米球和树枝状介孔二 氧化硅纳米球的孔结构进行表征;

通过热重分析(TG)、模拟释放实验和抑菌实验对制备的载药复合纳米球载药 量、释药性能及药效进行研究. 结果表明,MSNs 和dMSNs 的平均粒径分别为(210±10)和(235±10)nm,比表面 积分别为

1 092.867 和1289.110 m2 / g,孔容分别为 0.690 和0.814 cm3 / g,孔径分别为 32.144 和32.673 ?. He/ MSNs 和He/ dMSNs 载药率分别达到 42%和84%,且缓释作用明显. He/ MSNs 和He/ dMSNs(0.1 mg/ mL)对可可 毛色二孢菌均表现出良好的抑菌性能. 关键词:农药缓释制剂;

己唑醇;

纳米球;

介孔二氧化硅;

缓释性能 中图分类号:S767.1 文献标志码:A 文章编号:2096-1359(2019)03-0080-06 Preparation and property examinations of hexaconazole/ mesoporoussilica sustained release nanospheres XU Nanfang1 , XU Peng2? , CENG Changli2 , CHEN Nannan2 , SHAO Wei2 , TANG Jingen1 (1. College of Forestry, Nanjing Forestry University, Nanjing 210037, China;

2. College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China) Abstract:The chemical control is one of the most effective control methods for agriculture and forestry against pests and diseases. However, it also brings many problems such as pesticide residues, environmental pollution and drug re? sistance during the practical application. The sustained release pesticide has been considered as an effective method to solve the problems. Recently, the nanomaterials have been identified as potential targeted delivery carriers for pesti? cides. In particular, the mesoporous silica nanoparticles (MSNs) attributes include well defined and tunable pore sizes (2-50 nm), large pore volumes, high surface areas, chemical stability, resistance to microbial attack, nanostructures that can be tailored, easily modified surface properties, biocompatibility, and aqueous degradability. In addition, MSNs protect loaded guest molecules against environmentally induced enzymatic degradation since no swelling or po? rosity changes occur in response to external stimuli, such as, pH and temperature. Furthermore, MSNs are excellent pesticide delivery carriers, as their structural properties can be modified to either enhance or slow down release kinet? ics. Arguably, MSNs offered great promise for the fabrication of stimulus responsive and targeted pesticide delivery scaffolds. In this study, MSNs and dendritic mesoporous SiO2 nanospheres (dMSNs), fabricated by the St?ber meth? od, were used as carrier materials to prepare hexaconzole/ mesoporous SiO2 composite nanospheres (He/ MSNs) and hexaconzole/ dendritic mesoporous SiO2 composite nanospheres ( He/ dMSNs ), respectively. The Transmission electron microscopy (TEM), laser particle size analyzer, fourier transform infrared spectroscopy (FT?IR), thermo? gravimetric analysis (TG), and nitrogen physisorption were used to analyze the morphology, structure, and the drug contents for the prepared nanospheres. The results showed that the size of the MSNs and dMSNs were (210±10)nm and (235±10) nm, respectively. The specific surface areas of the MSNs and dMSNs reached