PDF《Extract of Pitaya Fruit》

Journal of Diseases and Medicinal Plants 2016;

2(4): 51-55 http://www.

sciencepublishinggroup.com/j/jdmp doi: 10.11648/j.jdmp.20160204.12 ISSN: 2469-8202 (Print);

ISSN: 2469-8210 (Online) Testicular Dysfunction in Male Rats Reversed by Ethanolic Extract of Pitaya Fruit Mohammad Kanedi1, * , Sutyarso1 , Siti Nurjanah2 , Lilik Koernia Wahidah2

1 Department of Biology, Faculty of Mathematics and Sciences, University of Lampung, Bandar Lampung, Indonesia

2 Department of Pharmacy, Faculty of Mathematics and Sciences, Tulang Bawang University, Bandar Lampung, Indonesia Email address: [email protected] (M. Kanedi) * Corresponding author To cite this article: Mohammad Kanedi, Sutyarso, Siti Nurjanah, Lilik Koernia Wahidah. Testicular Dysfunction in Male Rats Reversed by Ethanolic Extract of Pitaya Fruit. Journal of Diseases and Medicinal Plants. Vol. 2, No. 4, 2016, pp. 51-55. doi: 10.11648/j.jdmp.20160204.12 Received: July 15, 2016;

Accepted: July 18, 2016;

Published: August 26,

2016 Abstract: Sexual disorders have a great impact on men'

s life, so that is why efforts in searching materials and techniques for the effective treatment of safe and cheap still continued. However, many of the natural material that is claimed efficacious drugs for the high content of bioactive, particularly for sexual disorders, has not been scientifically tested. This study was designed and conducted to ascertain whether the dragon fruit (Hylocereus sp) which is claimed to be efficacious as an antioxidant as well as anti-aging, can be used as a remedy for sexual function disorders and fertility in male rats. Male Sprague-Dawley rats (Rattus novergicus) aged

10 C

12 weeks, grouped in to four consisted of six rats each, treated once daily for

25 days. Group

1 (control) was given

1 ml CMC 1%;

group

2 received extract of pitaya fruit at a dose of 500mg/kg;

group

3 treated with cyproterone acetate (CPA) at a dose of 25mg/kg;

whereas group

4 adminstered with 25mg/kg CPA and 500mg/kg of pitaya fruit extract. CPA treatment effectively reduces serum testosterone while pitaya fruit extract effectively enhances the androgen concentration;

increases spermatozoa counts, sperm viability, sperm motility, and spermatid counts. However, pitaya fruit fail to restore the decrease of primary spermatocyte due to CPA induction. So, the conclusion white pitaya fruit extract effectively increase the synthesis of testosterone and play a role spermiogenesis, thus the pitaya fruit herbs can be used as an enhancer of sexual activity and fertility in male. Keywords: Pitaya Fruit, Dragon Fruit, Hylocereus Sp, Antioxidant, Testicular Function, Steroidogenesis 1. Introduction The testes serve two functions that are highly organized and complex called spermatogenesis and steroidogenesis. Spermatogenesis includes all the processes involved in the production of gametes whereas steroidogenesis is the entire enzymatic reactions leading to the production of male sexual hormones called androgens [1, 2]. When either one of or both functions are impaired, for one or more reasons, then there was what is called testicular dysfunction. There are many environmental factors, either external or internal, which has been suggested to cause testicular dysfunction, such as exposure to toxic substances, noise, electronic radiation, smoke, or lifestyle [3]. Whatever the cause, testicular dysfunction may result in a decline in fertility and androgen deficiency. Both types of the disorder, especially androgen (testosterone) deficiency, greatly affect the quality of life of men, because of a decline in mood and libido, poor of concentration, difficulty in keeping erection, low energy, poor muscles strenght, and many more [4]. Due to the high influence of sexual disorders in men'