DOC《郝琴》

郝琴

一、个人简介 郝琴,女,41岁,研究员,博士,中国疾病预防控制中心传染病预防控制所莱姆病室副主任.

主要从事莱姆病的预防控制和科研工作.作为课题负责人主持国家自然科学基金项目一项(基金编号:31100105),并作为子课题负责人和主要完成人参与并完成了多项国家级课题,在莱姆病相关领域发表署名文章50余篇,其中第一或通讯作者文章20余篇,包括SCI论文10余篇.参与对吉林、内蒙古自治区的莱姆病流行病学调查及病原基因分型研究获省级三等奖三项(分别为第三,第五完成人).对LAMP方法在莱姆病螺旋体检测中的应用研究获发明专利一项(ZL201210157254.5,第一完成人).

二、主要研究方向 (1)莱姆病的流行病学、病原学、诊断技术及疫苗研究. (2)回归热的流行病学及诊断技术研究.

三、代表性科研项目 1.重组多价亚单位莱姆病疫苗研究(2016ZX10004001-004),2016.1-2020.12,子课题负责,主持本项目的研究. 2.中国伯氏疏螺旋体的比较基因组学研究(31100105),2012.1-2014.12,项目负责人,主持本项目的研究. 3.重要病媒生物监测和传播相关病原体检测技术研究(2012ZX10004219-007),2012.1-2015.12,子课题负责,负责本项目中莱姆病的相关研究工作. 4. 传染病实验室监测核心技术和技术体系研究(2012ZX10004-215),2012.1-2015.12,主要参与,负责本项目中莱姆病的相关研究工作. 5. 基于细菌基因组序列的分型技术(2013ZX10004221),2013.1-2015.12,主要参与,负责本项目中莱姆病的相关研究工作.

四、代表性论文、成果(2011年以来) 1. 成果 (1)"吉林省伯氏疏螺旋体基因分型的研究".吉林省科技进步三等奖(2011J30139). (2)获得发明专利一项:用于检测莱姆病螺旋体的环介导等温扩增法ZL201210157254.5. 2.论文 Qin Hao,et al. Genomic Characteristics of Chinese Borrelia burgdorferi Isolates. PLOS ONE | DOI:10.1371/journal.pone.0153149, April 19, 2016. Qin Hao, Xuexia Hou, Zhen Geng and Wan Kanglin. Distribution of Borrelia burgdorferi sensu lato in China. Journal of clinical microbiology. 2011,49(2):647-650. (3) Hao Qin, Geng Zhen, Hou Xuexia, et al. Seroepidemiological Investigation on Lyme Disease and Human Granulocytic Anaplasmosis among People Living in Forest Areas of Eight Provinces in China. Biomedical and Environmental Sciences. 2013,26(3):185-189. (4) Xuexia Hou+, Jianmin Xu+, Qin Hao*,et al. Prevalence of Borrelia burgdorferi sensu lato in rodents from Jiangxi, Southeastern China region.International Journal of Clinical and Experimental Medicine. 2014;

7(12):5563-5567. (5) Lin Zhang , Xiong Zhu , Xuexia Hou , Zhen Geng , Hai Chen , Qin Hao*.Test of

259 serums from patients with arthritis orneurological symptoms confirmed existence of Lyme disease in Hainan province, China. Int J Clin Exp Med. 2015;

8(6):9531-9536. (6) ZHANG Liu Li , HOU Xue Xia , GENG Zhen , LOU Yong Liang WAN Kang Lin#, HAO Qin#. Combination of Loop-Mediated Isothermal Ampli?cation Assay and Nested PCR for Detection of Borrelia burgdorferi sensu lato in Human Serum Samples.Biomedical and Environmental Sciences. 2015;

28(4): 312-315. (7) ZhouXin, Hou Xuexia, GengZhen, Zhao sulian, Wan Kanglin* HaoQin*. Establishment of Multiple Locus Variable-number Tandem Repeat Analysis Assay for Genotyping of Borrelia burgdorferi sensu lato Detected in China. Biomedical and Environmental Sciences. 2014,27(9):665-675. (8) LIU Zhi Yun1,2,3,+, HAO Qin1,+ , HOU Xue Xia1,+, et al. A Study on the Method of Western Blot for Diagnosis of Lyme Disease Infected with Borrelia afzelii in China. Biomed Environ Sci, 2013,26(3):190-200. (9) Duan Xuefei1#, Hao qin2#, Guo Xiaodi1, et al. Epidemiological and clinical features of three clustered cases co-infected with Lyme disease and Rickettsioses . Zoonoses and public health. 2013, 60:487-493. (10) LIU Wei, LIU Huixin, ZHANG Lin, HOU Xuexia, WAN Kanglin#, HAO Qin #* Evaluation of Six Recombinant Proteins in Serological Diagnosis of Lyme Borreliosis in China. Biomedica1 and Environmenta1 Sciences. 2016,29(5):323-330.