XLS《additionalfile5》

DifferentialexpressionprofilebetweenwildtypeandWrnhelicasemutantmouseembryonicfibroblasts log2(WS/WT) , SymmetricalFoldChange(WS/WT) , A , P-value , ProbeName , GeneName , SystematicName , Description , adjustedP-value(BH) -4.

81077774219441 , -28.0665093737168 , 7.34213228723963 , 3.1041431380469e-07 , A_51_P413059 , Mcpt8 , NM_008572 , Musmusculusmastcellprotease8(Mcpt8),mRNA[NM_008572] , 5.14238704490035e-05 -4.07095560786765 , -16.8065955525415 , 6.05282100844438 , 9.49904303210507e-07 , A_52_P48569 , Slc38a4 , NM_027052 , Musmusculussolutecarrierfamily38,member4(Slc38a4),mRNA[NM_027052] , 8.41180407173526e-05 -4.04581928331817 , -16.5163075516466 , 9.91399973380485 , 4.40865609003876e-07 , A_52_P363951 , Thbs1 , NM_011580 , Musmusculusthrombospondin1(Thbs1),mRNA[NM_011580] , 5.72110361052484e-05 -3.90432582405511 , -14.9733572267354 , 10.1582631258924 , 6.2019969766746e-07 , A_52_P10793 , Ptn , NM_008973 , Musmusculuspleiotrophin(Ptn),mRNA[NM_008973] , 7.15912258371069e-05 -3.64238176555804 , -12.4872316133529 , 8.35319263351352 , 1.32074704178825e-06 , A_51_P372819 , Ptgis , NM_008968 , MusmusculusprostaglandinI2(prostacyclin)synthase(Ptgis),mRNA[NM_008968] , 0.000103533682739205 -3.33491696936596 , -10.090438524481 , 6.12998569204826 , 1.21667463228837e-05 , A_52_P337092 , Thbs1 , NM_011580 , Musmusculusthrombospondin1(Thbs1),mRNA[NM_011580] , 0.000368904930959889 -3.18510950086199 , -9.09522608929504 , 8.88040788854899 , 1.33698428295275e-05 , A_51_P426195 , Nppb , NM_008726 , MusmusculusnatriureticpeptideprecursortypeB(Nppb),mRNA[NM_008726] , 0.000390642498673649 -3.16155913727961 , -8.94796204759494 , 9.90902086509015 , 3.17253126267719e-06 , A_51_P180747 , Ctla2a , NM_007796 , MusmusculuscytotoxicTlymphocyte-associatedprotein2alpha(Ctla2a),mRNA[NM_007796] , 0.00018208063354008 -3.11887578274432 , -8.68710685117528 , 8.83598437162962 , 3.48590002046301e-06 , A_51_P339793 , Il1rl1 , NM_010743 , Musmusculusinterleukin1receptor-like1(Il1rl1),mRNA[NM_010743] , 0.000186728044429469 -3.06728824309936 , -8.3819635230077 , 8.13566006727421 , 6.54879566738454e-06 , A_51_P281716 , Ltbp1 , NM_019919 , Musmusculuslatenttransforminggrowthfactorbetabindingprotein1(Ltbp1),transcriptvariant1,mRNA[NM_019919] , 0.000247621520882046 -3.05270279770216 , -8.29764995960588 , 6.05480964114115 , 4.02175152666279e-06 , A_52_P88007 , Slc6a7 , NM_201353 , Musmusculussolutecarrierfamily6(neurotransmittertransporter,L-proline),member7(Slc6a7),mRNA[NM_201353] , 0.000200381664359274 -3.04967604692558 , -8.28025987312417 , 10.427638327654 , 4.92240194021188e-06 , A_51_P157042 , Ctgf , NM_010217 , Musmusculusconnectivetissuegrowthfactor(Ctgf),mRNA[NM_010217] , 0.000216720545696452 -3.03277931273687 , -8.18384778912078 , 8.45133371636466 , 2.19952325202449e-05 , A_52_P436238 , Odc1 , NM_013614 , Musmusculusornithinedecarboxylase,structural(Odc),mRNA[NM_013614] , 0.000516465172942228 -3.01512922235086 , -8.08433565428454 , 10.9689976002795 , 4.32676209896382e-06 , A_52_P685021 , Cxcl12 , NM_021704 , Musmusculuschemokine(C-X-Cmotif)ligand12(Cxcl12),transcriptvariant1,mRNA[NM_021704] , 0.000201539324435793 -2.99066749658436 , -7.94841663363563 , 9.54866882937314 , 3.92709114601851e-05 , A_52_P298093 , Peli1 , NM_030015 , Musmusculuspellino1(Peli1),mRNA[NM_030015] , 0.000693498403478215 -2.88881096380919 , -7.4065976308677 , 7.8323330544489 , 7.3996184638143e-06 , A_51_P336770 , Aebp1 , NM_009636 , MusmusculusAEbindingprotein1(Aebp1),mRNA[NM_009636] , 0.000261344766403288 -2.88668024143506 , -7.39566686950376 , 7.76872727072592 , 6.1521237339953e-06 , A_51_P423484 , Rbp1 , NM_011254 , Musmusculusretinolbindingprotein1,cellular(Rbp1),mRNA[NM_011254] , 0.000240202936464578 -2.83506965421593 , -7.13577266659675 , 7.40856392700226 , 8.06222638590789e-06 , A_51_P110471 , Ddah1 , NM_026993 , Musmusculusdimethylargininedimethylaminohydrolase1(Ddah1),mRNA[NM_026993] , 0.000272757848466399 -2.81704688007503 , -7.0471839860719 , 7.7281409137214 , 6.20928622970488e-05 , A_52_P271572 , Ece2 , NM_139293 , Musmusculusendothelinconvertingenzyme2(Ece2),transcriptvariant2b-2,mRNA[NM_139293] , 0.000886962041878733 -2.8087424963623 , -7.00673579121973 , 7.69906337653415 , 8.31901117645147e-06 , A_52_P224760 , Ptgs2 , NM_011198 , Musmusculusprostaglandin-endoperoxidesynthase2(Ptgs2),mRNA[NM_011198] , 0.000278513561678281 -2.78083429023565 , -6.87249661064873 , 6.57417814914475 , 1.78803678084265e-05 , A_52_P592835 , Gucy1b3 , NM_017469 , Musmusculusguanylatecyclase1,soluble,beta3(Gucy1b3),mRNA[NM_017469] , 0.000459740017090261 -2.780094540768 , -6.86897360517424 , 7.22295017348045 , 9.60951884734415e-06 , A_52_P418791 , Rbp1 , NM_011254 , Musmusculusretinolbindingprotein1,cellular(Rbp1),mRNA[NM_011254] , 0.000308849935753641 -2.75663424565979 , -6.75817751419009 , 6.12294716849647 , 2.24969272594623e-05 , A_51_P455366 , Ankrd27 , NM_178263 , Musmusculusankyrinrepeatdomain27(VPS9domain)(Ankrd27),mRNA[NM_178263] , 0.000516465172942228 -2.71150724780871 , -6.55005603050709 , 8.04151506239322 , 0.000176396499099966 , A_51_P483499 , Serpinb9c , NM_011453 , Musmusculusserine(orcysteine)proteinaseinhibitor,cladeB,member9c(Serpinb9c),mRNA[NM_011453] , 0.00152402781749272 -2.68678524801178 , -6.43877058814054 , 6.38248835010477 , 1.81786372511105e-05 , A_52_P586157 , Cbfb , NM_022309 , Musmusculuscorebindingfactorbeta(Cbfb),mRNA[NM_022309] , 0.000460435064591786 -2.66484047543586 , -6.3415718411363 , 6.87824756450714 , 0.000198680707232724 , A_52_P598420 , Matn1 , NM_010769 , Musmusculusmatrilin1,cartilagematrixprotein1(Matn1),mRNA[NM_010769] , 0.00160256280965495 -2.65251065427643 , -6.28760529130043 , 6.38849976806686 , 2.69685793958069e-05 , A_52_P42255 , Crmp1 , NM_007765 , Musmusculuscollapsinresponsemediatorprotein1(Crmp1),mRNA[NM_007765] , 0.000572427332096008 -2.65131188356365 , -6.28238293576009 , 7.31354125889612 , 5.41505364030987e-05 , A_51_P324834 , Evpl , NM_025276 , Musmusculusenvoplakin(Evpl),mRNA[NM_025276] , 0.000820942566035657 -2.57837058164373 , -5.97264751592571 , 7.67794934333789 , 1.53370599093092e-05 , A_51_P375558 , Myoc , NM_010865 , Musmusculusmyocilin(Myoc),mRNA[NM_010865] , 0.000424942332314824 -2.54933711450973 , -5.85365254584636 , 6.09402331258288 , 0.0010013397201955 , A_52_P481493 , Fkbp5 , NM_010220 , MusmusculusFK506bindingprotein5(Fkbp5),mRNA[NM_010220] , 0.00353708225797409 -2.53083071530947 , -5.77904344353936 , 8.77086450314435 , 0.000168107058220912 , A_51_P338443 , Angptl4 , NM_020581 , Musmusculusangiopoietin-like4(Angptl4),mRNA[NM_020581] , 0.00148667534088853 -2.50911143389424 , -5.69269353211597 , 6.83412850935541 , 1.95340529910409e-05 , A_51_P133349 , Lats2 , NM_015771 , Musmusculuslargetumorsuppressor2(Lats2),mRNA[NM_015771] , 0.000482941894716964 -2.48725724542539 , -5.60710950495154 , 7.62899143259529 , 2.88193221151074e-05 , A_52_P462625 , Rras2 , NM_025846 , MusmusculusrelatedRASviral(r-ras)oncogenehomolog2(Rras2),mRNA[NM_025846] , 0.000597582588890034 -2.4760752564116 , -5.56381810899583 , 8.37491825371106 , 2.40327274277576e-05 , A_51_P348804 , Amotl2 , NM_019764 , Musmusculusangiomotinlike2(Amotl2),mRNA[NM_019764] , 0.00054350610667256 -2.46762570977043 , -5.53132729218375 , 10.8741362213263 , 0.000118204869754199 , A_52_P532910 , Tpm1 , NM_024427 , Musmusculustropomyosin1,alpha(Tpm1),mRNA[NM_024427] , 0.00124153742284312 -2.44120153461472 , -5.43093853144314 , 8.71279516656508 , 3.64216155786228e-05 , A_51_P291438 , Tnc , NM_011607 , MusmusculustenascinC(Tnc),mRNA[NM_011607] , 0.000662979217264953 -2.4359895713556 , -5.41135380762625 , 6.87839191325763 , 2.66052853741043e-05 , A_51_P517215 , Grb14 , NM_016719 , Musmusculusgrowthfactorreceptorboundprotein14(Grb14),mRNA[NM_016719] , 0.000570062581282474 -2.43392452567071 , -5.40361364168082 , 6.50046218739552 , 0.000421142662073575 , A_52_P490910 , Fndc4 , NM_022424 , MusmusculusfibronectintypeIIIdomaincontaining4(Fndc4),mRNA[NM_022424] , 0.00231052365770857 -2.42606129730651 , -5.3742420391267 , 10.387395363175 , 0.000184767436325121 , A_52_P662711 , Anxa13 , NM_027211 , MusmusculusannexinA13(Anxa13),mRNA[NM_027211] , 0.00156695745398273 -2.42031229773178 , -5.35286882011202 , 7.59895490370948 , 2.57263231634357e-05 , A_51_P352296 , Sfrp1 , NM_013834 , Musmusculussecretedfrizzled-relatedsequenceprotein1(Sfrp1),mRNA[NM_013834] , 0.000554........