XLS《S4Dataset》

EnrichmentofextracellularvesiclesfromtissuesofthecentralnervoussystembyPROSPR ,,

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, XavierGallart-Palau,AidaSerraandSiuKwanSze ,,

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, SupplementaryDataset4.

Listofproteinsidentifiedinhumanwholebrain.Databasesearcheswasperformedusinganin-houseMascotserver(version2.3.02,MatrixScience,MA,USA)withaprecursoriontoleranceof ,,

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, 10ppmandfragmentpeaktoleranceof0.05Da.Uniprothumandatabase(downloadedon15thJulyof2015,90478sequencesand35.890.546residues)wasusedfordatabasesearch.Twomissedtrypsincleavagesitesweretolerated. ,,

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, Carbamidomethylation(C)wassetasfixedmodificationanddeamidation(NQ)andoxidation(M)weresetasvariablemodifications.PeptideswithMascotscore>

15wereusedtogeneratethepeptidelistinalltestedhumanconditions. ,,

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, Accession , GS , Name , Mass , emPAI , SEM P68363 , TUBA1B , TBA1B_HUMANTubulinalpha-1BchainOS=HomosapiensGN=TUBA1BPE=1SV=1 ,

50804 , 292.095 , 97.4149999999998 P04350 , TUBB4A , TBB4A_HUMANTubulinbeta-4AchainOS=HomosapiensGN=TUBB4APE=1SV=2 ,

50010 , 1224.320625 , 305.96 P02768 , ALB , ALBU_HUMANSerumalbuminOS=HomosapiensGN=ALBPE=1SV=2 ,

71317 , 60.645 , 1.385 P68371 , TUBB4B , TBB4B_HUMANTubulinbeta-4BchainOS=HomosapiensGN=TUBB4BPE=1SV=1 ,

50255 , 1409.48125 , 760.72 Q71U36 , TUBA1A , TBA1A_HUMANTubulinalpha-1AchainOS=HomosapiensGN=TUBA1APE=1SV=1 ,

50788 , 274.25 , 91.4800000000001 Q13885 , TUBB2A , TBB2A_HUMANTubulinbeta-2AchainOS=HomosapiensGN=TUBB2APE=1SV=1 ,

50274 , 1560.13625 , 610.065 P63261 , ACTG1 , ACTG_HUMANActin,cytoplasmic2OS=HomosapiensGN=ACTG1PE=1SV=1 ,

42108 , 7098.255 , 2326.975 Q9BVA1 , TUBB2B , TBB2B_HUMANTubulinbeta-2BchainOS=HomosapiensGN=TUBB2BPE=1SV=1 ,

50377 , 1223.195625 , 541.565 P68366 , TUBA4A , TBA4A_HUMANTubulinalpha-4AchainOS=HomosapiensGN=TUBA4APE=1SV=1 ,

50634 , 120.840078125 , 33.69 P07437 , TUBB , TBB5_HUMANTubulinbetachainOS=HomosapiensGN=TUBBPE=1SV=2 ,

50095 , 1096.725 , 641.8653125 Q13748 , TUBA3C , TBA3C_HUMANTubulinalpha-3C/DchainOS=HomosapiensGN=TUBA3CPE=1SV=3 ,

50612 , 35.74001953125 , 4.60999999999999 P05023 , ATP1A1 , AT1A1_HUMANSodium/potassium-transportingATPasesubunitalpha-1OS=HomosapiensGN=ATP1A1PE=1SV=1 ,

114135 , 18.945009765625 , 4.43499999999999 Q16555 , DPYSL2 , DPYL2_HUMANDihydropyrimidinase-relatedprotein2OS=HomosapiensGN=DPYSL2PE=1SV=1 ,

62711 , 136.995078125 , 86.885 P14136 , GFAP , GFAP_HUMANGlialfibrillaryacidicproteinOS=HomosapiensGN=GFAPPE=1SV=1 ,

49907 , 2064.52125 , 1505.89 B1AKY9 , ATP1A2 , B1AKY9_HUMANSodium/potassium-transportingATPasesubunitalphaOS=HomosapiensGN=ATP1A2PE=1SV=1 ,

112046 , 20.280009765625 , 10.37 Q13509 , TUBB3 , TBB3_HUMANTubulinbeta-3chainOS=HomosapiensGN=TUBB3PE=1SV=2 ,

50856 , 189.475 , 17.895 P01023 , A2M , A2MG_HUMANAlpha-2-macroglobulinOS=HomosapiensGN=A2MPE=1SV=3 ,

164613 , 2.09000122070313 , 0.03 P68032 , ACTC1 , ACTC_HUMANActin,alphacardiacmuscle1OS=HomosapiensGN=ACTC1PE=1SV=1 ,

42334 , 697.435625 , 52.455 P61764 , STXBP1 , STXB1_HUMANSyntaxin-bindingprotein1OS=HomosapiensGN=STXBP1PE=1SV=1 ,

67925 , 98.890078125 , 2.36 P68133 , ACTA1 , ACTS_HUMANActin,alphaskeletalmuscleOS=HomosapiensGN=ACTA1PE=1SV=1 ,

42366 , 384.2903125 , 85.31 Q01082 , SPTBN1 , SPTB2_HUMANSpectrinbetachain,non-erythrocytic1OS=HomosapiensGN=SPTBN1PE=1SV=2 ,

275237 , 11.185 , 4.875 P21796 , VDAC1 , VDAC1_HUMANVoltage-dependentanion-selectivechannelprotein1OS=HomosapiensGN=VDAC1PE=1SV=2 ,

30868 , 539.565 , 232.675 A0A087WVQ6 , CLTC , A0A087WVQ6_HUMANClathrinheavychainOS=HomosapiensGN=CLTCPE=1SV=1 ,

193703 , 6.8050048828125 , 1.735 P12277 , CKB , KCRB_HUMANCreatinekinaseB-typeOS=HomosapiensGN=CKBPE=1SV=1 ,