PDF《如何才能更安全更有效的防控PRRS》

佑本疫苗 至纯至美 2018/12/4 ZFX版权

1 杭州佑本动物疫苗有限公司 Hangzhou Uben Animal Vaccine Co.

,Ltd 如何才能更安全更有效的防控PRRS How can we prevent and control PRRS more safely and effectively? 赵福相(技术服务总监) Zhao Fuxiang (Technical Service Director) 佑本疫苗 至纯至美 2018/12/4 ZFX版权

2 1 PRRS灭活疫苗免疫攻毒试验 Immune challenge test with PRRS inactivated vaccine PRRS灭活疫苗田间试验 Field trial of PRRS inactivated vaccine PRRS防控的挑战 The significance of PRRS prevention and control 结论Conclusion

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4 内容提要 Abstract 佑本疫苗 至纯至美 2018/12/4 ZFX版权

3 1 PRRS灭活疫苗免疫攻毒试验 Immune challenge test with PRRS inactivated vaccine PRRS灭活疫苗田间试验 Field trial of PRRS inactivated vaccine PRRS防控的挑战 The significance of PRRS prevention and control 结论Conclusion

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4 内容提要 Abstract 佑本疫苗 至纯至美 2018/12/4 ZFX版权

4 PRRS防控的挑战 The significance of PRRS prevention and control ? 国内PRRSV流行优势毒株经历了三个阶段: At present, PRRSV predominant strains have gone through three stages in China. ? 1.经典型PRRSV:1995年-2006年Classical PRRSV:1995-2006 ? 2.HP-PRRSV:2006年-2014年HP-PRRSV:2006-2014 ? 3.NADC30-like-PRRSV:2014年至今 NADC30-like-PRRSV:2014 to nowadays 佑本疫苗 至纯至美 2018/12/4 ZFX版权

5 新流行毒株NADC30-like感染的主要临床表现: The main clinical manifestations of NADC30-like infection in new epidemic strains: ? 母猪繁殖障碍 Reproductive disorder for sow ? 流产、早产 Abortion, premature delivery ? 不育(返情、后备猪不发情)Infertility(return to estrus, reserve swine fail to observe estrus) ? 保育仔猪呼吸障碍、运动障碍 Breathing disorder and dyskinesia for nursery piglet ? 消瘦、衰弱 Weight loss, weakness ? 严重继发感染 Severe secondary infection ? 高死亡率 High death rate 各种弱毒疫苗对其免疫保护均不理想. Various attenuated vaccines are unsatisfactory for immune protection. 佑本疫苗 至纯至美 2018/12/4 ZFX版权

6 PRRS疫苗的免疫挑战: The immune challenge with PRRS vaccine: ? PRRSV弱毒活疫苗在生产实践中的应用,加速了PRRSV的变异与重组,特点为: The application of PRRSV attenuated vaccine in practice has accelerated the variation and recombination of PRRSV. ? 变异广泛性 Extensive variability ? 毒株多样性 Viral diversity ? 病原复杂性 Pathogen complexity ? 在实际生产实践中,一个猪群中往往有多个流行毒株同时存在或单一存在. There are often multiple or single epidemic strain(s) present in a herd in practice. 佑本疫苗 至纯至美 2018/12/4 ZFX版权

7 PRRS疫苗的免疫挑战: The immune challenge with PRRS vaccine: ? 同源基因型的弱毒苗是有效的,但弱毒苗免疫后有一段带毒期;

Attenuated vaccines of homologous genotypes are effective, but have a period of vaccine virus after immunization. ? 猪群机体长期存在PRRSV病毒血症是变异、重组的基础;

The long-term presence of PRRSV viremia in pig herds is the basis for mutation and recombination. ? PRRS弱毒苗因变异、重组等特性,使其安全使用受到了质疑. PRRS attenuated vaccines have been questioned due to their safety of variability and recombination. ? PRRS灭活苗呢? What about the PRRS inactivated vaccine? 佑本疫苗 至纯至美 2018/12/4 ZFX版权

8 关于PRRSV灭活疫苗效果 The effect of PRRSV inactivated vaccine ? 灭活苗是不是更安全更有效的防控方式呢? Is the inactivated vaccine a safer and more effective way to prevent and control PRRSV ? ? 有的学者认为无效(未测到免疫后中和抗体) Some scholars believe that it is ineffective , because there is no neutralizing antibody after immunization. ? 《猪病学》10版:通常认为,灭活疫苗的免疫保护较差,但如果与减毒疫苗联合运用或者用于之 前感染过PRRSV的猪时,会刺激记忆免疫应答反应并诱导产生良好的中和反应. Hyoiatrics in 10th edition point out it is generally believed that inactivated vaccines have poor immune protection ,but if used in combination with attenuated vaccines or in pigs that have previously been infected with PRRSV, they can stimulate the immune response and induce good neutralization reaction. ――通过试验证实? Confirmed by experiment? 佑本疫苗 至纯至美 2018/12/4 ZFX版权