DOC《2018年度广西科技技术奖推荐项目公示表》

但与儿童患者相比,成人患者更容易出现癫痫持续状态,这可能是导致成人抗 NMDA 受体脑炎预后不良的主要原因之一.同时,基于长达5年的随访数据,课题组发现及时地、规范地免疫干预治疗对于预后尤为重要,而抗癫痫药物的早期撤药,对痫性发作及认知障碍无明显影响.该研究成果对抗NMDA受体脑炎的诊治及癫痫后认知损伤的防治有广泛的临床应用意义和价值. (5)基于Morris水迷宫,建立了癫痫伴认知功能障碍的评价体系.通过记录正常大鼠、PTZ 致痫鼠 MWM 试验结果,利用统计归类分析,得出正常大鼠在 Morris 行为学测试中,第5天定位航行实验中逃避潜伏期20 次;

以此作为 TLE-C、TLE-CI分界参考,计算在所有 PTZ 致痫大鼠中,记忆障碍发生率为 19.23%.该评估体系已运用于后续实验中,并在相关院校、实验室中得到广泛的应用. 在项目研究过程中,课题组主持相关领域课题4项,发表相关论文30篇,其中SCI论文19篇.通过本项目的研究,培养了博士生7名,硕士生25名.研究成果多次于国内外神经病学、癫痫等专科会议上报告发言;

并通过国家级及自治区及继续教育培训项目等多种形式向省内外多家医院、科研机构进行推广,间接取得较好的社会和经济效益,具有广阔的推广应用前景. 知识产权情况 无 论文专著目录 1. Liu, X., et al., Grouping Pentylenetetrazol-Induced Epileptic Rats According to Memory Impairmentand MicroRNA Expression Profiles in the Hippocampus. PLoS One, 2015. 10(5): p. e0126123. 2. Huang, Q., et al., P38 MAPK pathway mediates cognitive damage in pentylenetetrazole-inducedepilepsy via apoptosis cascade. Epilepsy Res, 2017. 133: p. 89-92. 3. Liao, Y., et al., MicroRNA-328a regulates water maze performance in PTZ-kindled rats. Brain ResBull, 2016. 125: p. 205-10. 4. Huang, Y., et al., MiR-181a influences the cognitive function of epileptic rats induced by pentylenetetrazol. Int J Clin Exp Pathol, 2015. 8(10): p. 12861-8. 5. Yiqing Huang, X.L., Yuan Wu., The role of miR-34c on cognitive function of epileptic rats induced by pentylenetetrazol. Mol Med Rep. 2018. 17(3):p. 4173-4180. 6. Liu, X., et al., MicroRNA expression profiles in chronic epilepsy rats and neuroprotection from seizures by targeting miR-344a. Neuropsychiatr Dis Treat, 2017. 13: p. 2037-2044. 7. 廖亚云, et al., Let-7c-1 对戊四氮致痫大鼠学习记忆功能的作用. 中国神经精神疾病杂志, 2017.43(4): p.239-6. 8. Huang, J., et al., Expression level and distribution of HMGB1 in Sombati'

s cell model and kainic acid-induced epilepsy model. Eur Rev Med Pharmaco, 2015.8:p. 2928-2933. 9. 李瓶, et al.,Sombati细胞模型中Toll样受体4的表达及意义. 中国病理生理杂志, 2014. 1: p. 175-179. 10. 覃维含, et al.,海人酸致痫大鼠脑内白蛋白、S100B及GFAP动态表达的研究. 中国神经免疫学和神经病学杂志, 2015. 6, p. 424-429. 11. 陈镇, et al.,KA癫痫大鼠ALK5对TGF-β1-ALK1-p-Smad1通路的影响. 中风与神经疾病杂志, 2014.31(11) : p.977-981. 12. Huang, Q.,et al., Structural differences in interictal migraine attack after epilepsy: A diffusion tensor imaging analysis. Epilepsy behav, 2017. 77: p. 8-12. 13. 韦兴, et al., 抗N-甲基-D-天冬氨酸受体脑炎1例报告. 癫痫与神经电生理学杂志, 2013, 5: 319-320. 14. Huang, Q., et al., Clinical characteristics and outcomes between children and adults with anti-N-Methyl-D-Aspartate receptor encephalitis. J Neurol, 2016. 263(12): p. 2446-2455. 15. Huang, Y., et al., The genetic relationship between epilepsy and hemiplegic migraine. Neuropsychiatr Dis Treat, 2017. 13: p. 1175-1179. 16. Zou, D., et al., DREADD in parvalbumin interneurons of dentate gyrus modulates anxiety, social interaction and memory extinction. Curr Mol Med, 2016. 16(1):91-102. 17. Luo, C., et al., The role of microglia in multiple sclerosis. Neuropsych Dis Treat, 2017.13:1661-1667. 18. Luo, C., et al., TRB3 modulates microglial/macrophages polarization via down-regulating PPAR-gamma in rats suffering from diabetic cerebral ischemia. Int J Clin Exp Med, 2017. 10(9):14136-14145. 19. Wu Y., et al., Dl-3-n-butylphthalide is effective for demyelination: a case-combined study. Clin Neurol Neurosurg, 2015. 137:83-8. 20. Huang, Q., et al., Phylogenetic and structural analysis of the phospholipase A2 gene family in vertebrates. Int J Mol Med, 2015.35(3):587-96. 21. Huang, Q., et al., Evolutionary analysis of voltage-gated potassium channels by Bayes method. J Mol Neurosci, 2014, 53(1):41-9. 项目标准情况 无 项目完成单位取得的直接经济效益及其计算依据 无 其他单位应用项目技术产生的经济效益 无 其他应用单位及经济效益列表 无 完成单位 广西医科大学 完成人排名及对项目的贡献 姓名 排名 工作单位 完成单位 职称 技术创造性贡献 吴原