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reliability and comprehensiveness of trait definitions and phenotypic and exposure measures;

diversity of ancestry, geographical region of origin and gender of study subjects;

and potential overlap with ongoing studies. DNA specimen criteria included adequacy and consistency of DNA amount and concentration and speci- men quality, as assessed by platform-specific SNP assay pass rates for roughly 3,200 SNPs in randomly selected samples submitted by each applicant.Power and analysis criteria included appropriateness of assumptions,impact of rec- ommended reductions or increases in sample size,appropriateness of proposed analyses and availability of suitable follow-up samples.Data sharing and consent criteria included restric- tions on the research use of data and samples (such as limitation to a single disease or to noncommercial investigators), adequacy of the procedure for obtaining consent for GWA genotyping and data sharing and provisions for t........