PDF《the SMART database.》

1 Online Supporting Information S2.

List of the 12,810 functional domain names in the SMART database. 14_3_3 35EXOc 4.1m 53EXOc A1pp A4_EXTRA AAA AAA_PrkA AAI Aamy Aamy_C AARP2CN acidPPc ACR ACTIN ADEAMc Adenylsucc_synt ADF Ad_cyc_g-alpha AFOR_N Agenet Agglutinin Agouti AgrB AgrD Agro_virD5 AGTRAP AHS1 AHS2 AICARFT_IMPCHas AIP3 AKAP_110 ALBUMIN alkPPc Alpha-amyl_C2 Alpha-L-AF_C Alpha-mann_mid Alpha_adaptinC2 Alpha_kinase Alpha_L_fucos Alpha_TIF AMA-1 Amb_all Amb_V_allergen Amelin Amelogenin Ami_2 Ami_3 AMOP ANATO ANK ANX AP2 AP2Ec APPLE AraC_E_bind ARF ArfGap ARM Asparaginase AT_hook Autotransporter AWS AXH A_amylase_inhib B3_4 B41 B5 B561 BACK Bac_DnaA_C BAG BAH BAR BASIC BATS BBC BBOX BCL BH4 BHL BID_1 BID_2 Biotin_carb_C BIR BMC BON BowB BPI1 BPI2 BRCT BRIGHT Brix BRK BRLZ BROMO BSD BTB btg1 BTK BTP B_lectin C1 C1Q C2 C345C C4 C8 CA CAD CADG CALCITONIN calpain_III Calx_beta CAP10 CARD CARP CASc CASH Cation_ATPase_N CBD_II CBD_IV CBF

2 CBS CCP CENPB CFEM CH CHAD CheW CHK CHRD CHROMO ChSh ChtBD1 ChtBD2 ChtBD3 ChW Citrate_ly_lig CLa CLb CLECT CLH CLIP CM_2 CNH cNMP CNX CoA_binding CoA_trans CobW_C Cog4 coiled_coil_region COLFI COLIPASE CPDc Cpn10 CRA CRF CSF2 CSP CT CTLH CTNS CUB CUE CULLIN Cullin_Nedd8 Cupin_1 Cu_FIST CW CxxC_CXXC_SSSS CY CYCc CYCLIN CysPc D5_N Dabb DAGKa DAGKc DALR_1 DALR_2 DAX DCD DCX dDENN DDT DEATH DED DEFSN DENN DEP DEXDc DEXDc2 DEXDc3 DISIN DM DM10 DM11 DM13 DM14 DM15 DM16 DM3 DM4_12 DM5 DM6 DM7 DM8 DM9 DnaG_DnaB_bind DnaJ DNaseIc DoH DPBB_1 DSL DSPc DSRM DUSP DWA DWB DYNc DysFC DysFN DZF EAL EB_dh EF1_GNE EFG_C EFG_IV EFh EGF EGF_CA EGF_Lam EGF_like EH eIF1a eIF2B_5 eIF5C eIF6 EKR ELFV_dehydrog Elong-fact-P_C Elp3 END ENDO3c Endonuclease_NS ENTH EPEND EPH_lbd ERCC4 ETF ETS Excalibur EXOIII

3 EZ_HEAT FA58C FABD Fapy_DNA_glyco FAS1 FBD FBG FBOX fCBD FCD FCH FDX-ACB FeoA FES Fe_hyd_SSU FF FGF FH FH2 FHA FIMAC FIST Flavin_Reduct Flavokinase Flu_M1_C FMN_bind FN1 FN2 FN3 FolB FOLN FRG FRI FTP FtsA Ftsk_gamma FU Fungal_trans FYRC FYRN FYVE G2F GA GAF Gal-bind_lectin GAL4 Galanin GAS2 GASTRIN GatB_Yqey GDNF GED GEL Germane GGDEF GGL GHA GHB GIT GIYc GLA GLECT GLUCA Glyco_10 Glyco_18 Glyco_25 Glyco_32 GoLoco GPS Gp_dh_N GRAM GRAN Grip GS GuKc GYF GYR G_alpha G_patch H15 H2A H2B H3 H4 HA2 Haemagg_act HALZ HAMP HAT HATPase_c HDAC_interact HDc HECTc HELICc HELICc2 HELICc3 HEPN HhH1 HhH2 HintC HintN HIRAN HisKA HLH HMG HMG17 HNHc HNS HOLI HormR HOX HPT Hr1 HRDC HSA HSF HTH_ARAC HTH_ARSR HTH_ASNC HTH_CRP HTH_DEOR HTH_DTXR HTH_GNTR HTH_ICLR HTH_LACI HTH_LUXR HTH_MARR HTH_MERR HTH_XRE HTTM HWE_HK HX

4 HYDRO IB IBN_N IBR IDEAL IENR1 IENR2 IFabd IG IGc1 IGc2 IGv IG_FLMN IG_like IL1 IL10 IL2 IL4_13 IL6 IL7 IlGF ILWEQ INB Inhibitor_I29 Int_alpha IPPc IPT IQ IRF IRO ITAM JAB_MPN Jacalin JHBP JmjC JmjN KAZAL Kelch KH KIND KISc Knot1 KOW KR KRAB KU Ku78 L27 L51_S25_CI-B8 LA Lactamase_B LamB LamG LamGL LamNT LCCL LDLa LEM LeuA_dimer LH2 LIF_OSM LIGANc Lig_chan-Glu_bd LIM LINK LisH LITAF LMWPc LNS2 LON LPD_N LRR LRRcap LRRCT LRRNT LRR_BAC LRR_CC LRR_RI LRR_SD22 LRR_TYP LU LY LysM LytTR LYZ1 LYZ2 MA MA3 MACPF Mad3_BUB1_I MADF MADS Malic_M MAM MANEC MATH MBD MBT MbtH MCM MD MeTrc MGS MgtE_N MHC_II_alpha MHC_II_beta MIF4G MIR MIT ML MltA MoCF_biosynth Molybdop_Fe4S4 MORN MR_MLE Mterf MutH MutL_C MUTSac MUTSd MYSc MyTH4 NADH-G_4Fe-4S_3 NADH_4Fe-4S NAT_PEP NDK NEAT NEBU NEUZ Nfu_N NGF NGN

5 NH NIDO NIL NL NMU NOSIC NPCBM NRF NTR NUC NurA OLF OMPdecase OmpH ORANGE OSTEO P-II P4Hc PA14 PA2c PAC PAH PAM PAN_AP ParB PAS PASTA PAW PAX PAZ PB1 PBD PbH1 PBP5_C PBPb PBPe PCRF PD PDGF PDZ Pept_C1 PepX_C PepX_N Pfam:1-cysPrx_C Pfam:120_Rick_ant Pfam:14-3-3 Pfam:2-Hacid_dh Pfam:2-Hacid_dh_C Pfam:2-oxoacid_dh Pfam:2-ph_phosp Pfam:2CSK_N Pfam:2C_adapt Pfam:2Fe-2S_Ferredox Pfam:2H-phosphodiest Pfam:2HCT Pfam:2OG-FeII_Oxy Pfam:2_5_RNA_ligase Pfam:3-alpha Pfam:3-dmu-9_3-mt Pfam:3-HAO Pfam:3-PAP Pfam:3A Pfam:3Beta_HSD Pfam:3D Pfam:3H Pfam:3HBOH Pfam:3HCDH Pfam:3HCDH_N Pfam:3_5_exonuc Pfam:4F5 Pfam:4HBT Pfam:4_1_CTD Pfam:5-FTHF_cyc-lig Pfam:5-nucleotidase Pfam:53-BP1_Tudor Pfam:5HT_transporter Pfam:5TM-5TMR_LYT Pfam:5_3_exonuc Pfam:5_3_exonuc_N Pfam:5_nucleotid Pfam:5_nucleotid_C Pfam:60KD_IMP Pfam:6PF2K Pfam:6PGD Pfam:7kD_coat Pfam:7kD_DNA_binding Pfam:7TM-7TMR_HD Pfam:7TMR-DISMED2 Pfam:7TMR-DISM_7TM Pfam:7TMR-HDED Pfam:7tm_1 Pfam:7tm_2 Pfam:7tm_3 Pfam:7tm_6 Pfam:7tm_7 Pfam:7TM_GPCR_Sra Pfam:7TM_GPCR_Srab Pfam:7TM_GPCR_Srb Pfam:7TM_GPCR_Srbc Pfam:7TM_GPCR_Srd Pfam:7TM_GPCR_Srh Pfam:7TM_GPCR_Sri Pfam:7TM_GPCR_Srj Pfam:7TM_GPCR_Srsx Pfam:7TM_GPCR_Srt Pfam:7TM_GPCR_Sru Pfam:7TM_GPCR_Srv Pfam:7TM_GPCR_Srw Pfam:7TM_GPCR_Srx Pfam:7TM_GPCR_Srz Pfam:7TM_GPCR_Str Pfam:87kDa_TransP Pfam:A-2_8-polyST Pfam:A1_Propeptide Pfam:A2L_zn_ribbon Pfam:A2M Pfam:A2M_comp Pfam:A2M_N Pfam:A2M_N_2 Pfam:A2M_recep Pfam:A4_EXTRA Pfam:AAA Pfam:AAA-ATPase_like Pfam:AAA_2 Pfam:AAA_3 Pfam:AAA_4 Pfam:AAA_5 Pfam:AAA_PrkA Pfam:AalphaY_MDB Pfam:AAL_decarboxy Pfam:AAR2 Pfam:AARP2CN