PDF《 个人概况》

1 ? 个人概况 姓名:高敏杰 出生年月:1980 年12 月 研究室

电话:0510-85918299 通信地址:江苏省无锡市蠡湖大道

1800 号江南大学生物工程学院 A405 室 电子

邮箱:gaominjie@msn.

com;

[email protected] ? 研究方向: 发酵过程优化与控制 计算机技术与软件专业技术资格高级程序员 (软件设计师) ? 教育工作经历 2012.05 至今 江南大学 生物工程学院 副教授 2007.09~ 2012.03 江南大学 生物工程学院 发酵工程 博士 2005.09~2007.07 江南大学 生物工程学院 生物化工 硕士 2003.09~2005.07 江南大学 生物工程学院 辅导员 1999.09~2003.07 无锡轻工大学 生物工程学院 生物工程 学士 ? 科研项目:

1、主持国家自然科学基金 (极高细胞密度下乙醇历史积累抑制毕赤酵母表达外源蛋白 的分子机制及解抑制策略研究 No. 31301408);

2014.1-2016.12

2、主持江苏省自然科学基金 (乙醇历史积累抑制毕赤酵母表达蛋白的机制及解抑制策 略No. BK20130122).2013.7-2016.6

3、主持中国博士后科学基金(诱导前比生长速率影响毕赤酵母诱导启动效率的机制研 究No. 2014M551501) ;

2014.6-2015.12

4、主持江南大学自主科研计划-重点项目(高粘度、高密度发酵过程关键技术与装备 JUSRP51632A)2016.1-2018.12,100 万元

2

5、 主持江苏省政策引导类计划(产学研合作)--前瞻性联合研究项目(毕赤酵母高效 吸附稀贵金属离子关键技术研发及产业化 BY2016022-15)2016.7C2018.6 ? 期刊论文 1. Jian Ding, Lu-qiang Jia, Enock Mpofu, Min-Jie Gao* , Xi-dong Ren* . An On-line Adaptive Glucose Feeding System Incorporating Patterns Recognition for Glucose Concentration Control in Glutamate Fermentations,Biotechnology and Bioprocess Engineering,2016, 21(6): 758-766 2. Min-Jie Gao, Xiao-Bei Zhan, Peng Gao, Xu Zhang, Shi-Juan Dong, Zhen Li, Zhong-Ping Shi, Chi-Chung Lin. Improving performance and operational stability of porcine interferon-α production by Pichia pastoris with combinational induction strategy of low temperature and methanol/sorbitol co-feeding. Applied Biochemistry and Biotechnology, 2015, 176(2): 493-504. 3. Min-Jie Gao, Cheng Wang, Zhi-Yong Zheng, Li Zhu, Xiao-Bei Zhan, Chi-Chung Lin. Improving arachidonic acid fermentation by Mortierella alpina through multi-Stage temperature and aeration rate control in bioreactor. Preparative Biochemistry and Biotechnology, 2015, DOI: 10.1080/10826068.2015.1031397, 2016, 46(4):360-367. 4. Min-Jie Gao, Zhi-Yong Zheng, Jian-Rong Wu, Shi-Juan Dong, Zhen Li, Hu Jin, Xiao-Bei Zhan, Chi-Chung Lin. Improvement of specific growth rate of Pichia pastoris for effective porcine interferon-α production with an on-line model based glycerol feeding strategy. Applied Microbiology and Biotechnology, 2012, 93(4): 1437-1445. 5. Min-Jie Gao, Shi-Juan Dong, Rui-Song Yu, Jian-Rong Wu, Zhi-Yong Zheng, Zhong-Ping Shi, Xiao-Bei Zhan. Improvement of ATP regeneration efficiency and operation stability in porcine interferon-α production by Pichia pastoris under lower induction temperature. Korean Journal of Chemical Engineering, 2011, 28(6): 1412-1419. 6. Min-Jie Gao, Zhen Li, Rui-Song Yu, Jian-Rong Wu, Zhi-Yong Zheng, Zhong-Ping Shi, Xiao-Bei Zhan, Chi-Chung Lin. Methanol/sorbitol co-feeding induction enhanced porcine interferon-α production by P. pastoris associated with energy metabolism shift. Bioprocess and Biosystems Engineering, 2012, 35(7): 1125-1136. 7. Min-Jie Gao, Zhong-Ping Shi. Process control and optimization for heterologous protein productions by methylotrophic Pichia pastoris. Chinese Journal of Chemical Engineering, 2013, 21(2): 216-226. 8. Min-Jie Gao, Xiao-Bei Zhan, Zhi-Yong Zheng, Jian-Rong Wu, Shi-Juan Dong, Zhen Li, Zhong-Ping Shi, Chi-Chung Lin. Enhancing pIFN-α production and process stability in fed-batch culture of Pichia pastoris by controlling the methanol concentration and monitoring the responses of OUR/DO levels. Applied Biochemistry and Biotechnology, 2013, 171: 1262-1275.

3 9. Li-Bo Yang, Xiao-Bei Zhan, Li Zhu, Min-Jie Gao, Chi-Chung Lin. Optimization of a low-cost hyperosmotic medium and establishing the fermentation kinetics of erythritol production by Yarrowia lipolytica from crude glycerol. Prep Biochem Biotechnol, 2016, 46(4): 376-383. 10. Jian Ding, Min-Jie Gao, Guo-Li Hou, Ke-Xue Liang. Effect of ethanol accumulation on porcine interferon-α production by Pichia pastoris and activities of key enzymes in carbon metabolism. Applied Biochemistry and Biotechnology, 2015, 176:1964-1974. 11. Jian Ding, Min-jie Gao, Guo-li Hou, Ke-xue Liang, Rui-song Yu, Zhen Li, Zhong-ping Shi. Stabilizing porcine interferon-α production by Pichia pastoris with an ethanol on-line measurement based DO-Stat glycerol feeding strategy. Journal of Chemical Technology & Biotechnology, 2014, 89(12): 1948-1953. 12. Jian Ding, Chun-ling Zhang, Min-jie Gao, Guo-li Hou, Ke-xue Liang, Chun-hua Li, Jian-ping Ni, Zhen Li, Zhong-ping Shi. Enhanced porcine circovirus Cap protein production by Pichia pastoris with a fuzzy logic DO control based methanol/sorbitol co-feeding induction strategy. Journal of Biotechnology, 2014, 177: 35-44. 13. 高鹏,丁健,张许,赵h,张猛,高敏杰*,吴剑荣* ,詹晓北. 乙醇胁迫抑制毕赤酵 母表达外源蛋白的转录组学分析. 生物工程学报. 2016, 32(6): 1-15. ? 专利 1. 詹晓北, 郑志永, 高敏杰, 丁春华. 一种应用于发酵罐的错流导向式搅拌桨. 专利号: ZL201310577861.1 2. 詹晓北, 朱莉, 向荣华, 郑志永, 吴剑荣, 高敏杰,张洪涛. 一种瓶载真姬菇 的方法. 专利号:ZL201310564418.0 3. 高敏杰,詹晓北,史仲平,丁健,杨帅. 一种重组毕赤酵母表达外源蛋白过程的专家 控制系统. 专利号: ZL201410767928.2 4. 詹晓北,高敏杰,史仲平,郑志永,丁健,杨帅. 一种基于支持向量机的毕赤酵母发 酵过程预警. 专利号: 201410803931.5 5. 高敏杰,詹晓北,史仲平,丁健,蒋芸,潘晴. 一种提高大肠杆菌聚唾液酸产量的专 家控制系统. 专利号: ZL201410815552.8 6. 高敏杰,洪瀚,詹晓北,李志涛,沈宇峰,郑志永. 一种利用氯化钙处理毕赤酵母吸 附废水中铑离子的方法. 专利申请号:201611025072.7 7. 高敏杰,洪瀚,詹晓北,李志涛,沈宇峰,郑志永. 一种利用盐酸处理毕赤酵母吸附 废水中铑离子的方法. 专利申请号:201611025002.1