PDF《PHARMACOLOGY》

EDITOR John A.

Harvey ASSISTANT EDITOR Jay Roberts Cellular and Molecular Pharmacology Toshio Narahashi Ronald P. Rubin George B. Weiss Chemotherapy/Gene Therapy Jonathan Maybaum Developmental Pharmacology Hazel H. Szeto Drug Metabolism and Disposition Arthur Cho David Kupfer Grant R. Wilkinson EXECUTIVE OFFICER OF THE SOCIETY Kay A. Croker TheJournalof PHARMACOLOGY Volume

275 October-December AND EXPERIMENTAL THERAPEUTICS

1995 A Publication of The American Society for Pharmacology and Experimental Therapeutics EDITORS FOR SPECIFIC FIELDS Founded by John J. Abel

1909 Analgesia and Drugs of Abuse Alan Cowan Billy R. Martin Frank Porreca Autonomic Pharmacology Suzanne G. Laychock Kenneth P. Minneman Behavioral Pharmacology Linda A. Dykstra Lewis S. Selden Cardiovascular Pharmacology Gregory D. Fink Allan M. Lefer Benedict R. Lucchesi Harry S. Margolius R. Clinton Webb Martin W. Adler Edson X. Albuquerque Julius C. Allen William D. Atchison Leslie Ballou Paul Bass Bruce P. Bean Donald M. Bers C. Paul Bianchi Vernon S. Bishop Floyd E. Bloom Peter G. Bradford Craig D. Brater David Brooks Steve R. Childers Theodore J. Cicero Ronald G. Coffey Marlene L. Cohen Allan C. Collins Charles R. Craig Kathryn A. Cunningham Cathy A. Davison William C. de Groat Gary E. DeLander Louis Diamond Walter R. Dixon Thomas V. Dunwiddie Jerry M. Farley Harold Feinberg Dan J. Feller John Ferkany Kevin Finnegan Stephen K. Fisher Garret A. FitzGerald Stephen F. Flaim Endocrine Pharmacology Paula H. Stem Gastrointestinal Pharmacology David R. Brown James J. Galllgan Immunopharmacology John W. Hadden Neuropharmacology S. J. Enna James W. Glbb Barry J. Hoffer Michael J. Kuhar David R. Manning EDITORIAL ADVISORY BOARD Jerome H. Fleisch Robert B. McCall Alan Fraser John R. McCullough Peter A. Friedman Donald E. McMillan Ray W. Fuller Kaushik D. Meisheri Kathleen Giacomini Daniel T. Monaghan Alasdair Gilifilan William H. Morse Kathleen Grant Hasan Mukhtar Thomas P. Green Albert E. Munson Thomas M. Guenthner L. Charles Murrin Glen R. Hanson Norton H. Neff R. Adron Harris Kim A. Neve Thomas G. Heffner Jon A. Norman J. Paul Hieble Eliot H. Ohlstem Ronald Hines Achilles J. Pappano Paula L. Hoffman Gal W. Pasternak Jordan Holtzman William H. Percy Stephen G. Holtzman Michael Piascik Jerry B. Hook Garth Powis Joseph R. Hume Edwin K Jackson Kenzie L. Preston E. H. Jeffery Russell A. Prough Kenneth M. Johnson Richard A. Rabin Peter W. Kalivas David Raeburn George J. Kaloyanides Satish Rattan Nancy George A. Ricaurte Robert S. Fass Sandra C. Roerig Terry Kenakin Michael C. Sanguinetti Lewis B. Kinter Saul M. Schanberg David D. Ku Christopher J. Schmidt Roberto Levi Michal L. Schwartzman George E. Lindenmayer Ronald Shebuaki James Lohr Paul J. Silver Irwin Lucid Kenny J. Simansky Joseph Lynch David J. Smith Prostaglandins, Leukotrienes and Other Etcosanoids K. U. Malik Pulmonary Pharmacology Mannfred A. Hollinger Renal Pharmacology Margaret A. Acara Jack W. Strandhoy Toxicology Curtis D. Klaassen Philip L. Smith Roger P. Smith Edward E. Soltis Patricia K Sonsalla Roger D. Spealman John L. Sutko Boris Tabakoff David A. Taylor Milt Teitler Thomas R. Tephly Richard E. Tessel Martin J. M. C. Thoolen Pieter B. M. W. M. Timmermans Myron L Toews Theodore J. Torphy John T. Turner Bradley J. Undem Norman J. Uretsky Paul M. Vanhoutte Robert E. Vestal Larry A. Walker Martin A. Wasserman Margaret T. Weis Sandra P. Welch H. Steve White Michael Williams Patricia D. Williams Steve Wilson Martin M. Winbury Raymond J. Winquist Jeffrey M. Witkin Bryan K Yamamoto Alice M. Young Edward J. Zambraski Michael J. Zigrnond BOARD OF PUBLICATIONS TRUSTEES Kenneth E. Moore, Chairman: William 0. Berndt, D. Craig Brater, David B. Bylund, William A. Catterall, Marlene L. Cohen, Raymond Dingledine, John A. Harvey, Raymond F. Novak, Marcus M. Reidenberg EDITOR John A. Harvey Cellular and Molecular Pharmacology Toshio Narahashi Ronald P. Rubin George B. Weiss Chemotherapy/Gene Therapy Jonathan Maybaum Developmental Pharmacology Hazel H. Szeto Drug Metabolism and Disposition Arthur Cho David Kupfer Grant R. Wilkinson EXECUTIVE OFFICER OF THE SOCIETY Kay A. Croker TheJournalof PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS A Publication of The American Society for Pharmacology and Experimental Therapeutics Founded by John J. Abel