PDF《LPS stimulation》

however, bioinformatics and experimental data have shown that there is a read-through from the Tmed7 gene into the Ticam2 gene, and this results in the expression of three genes, TMED7, TRAM and TAG9,18. Figure 1a demonstrates how TMED7, TRAM and TAG are generated. TMED7 is a

224 amino acid protein containing the GOLD domain of TAG, but no TIR domain, plus a putative coilC coil domain. TMED7 has two putative transmembrane domains, one near its N terminus (aa 17C34) and another near its C terminus (aa 186C207). TMED7 and TRAM share no sequence identity. We analysed the TMED7, TAG and TRAM mRNA expression profi........