PDF《贾彦兴》

贾彦兴 个人信息: 生于

1975 年5月1日,河北满城 地址 北京大学药学院、天然药物及仿生药物国家重点实验室 北京市海淀区学院路

38 号,100191 电话 &

传真: +86-10-82805166 联系

邮箱: yxjia@bjmu.

edu.cn 学习经历: 1993-1997 理学学士,兰州大学化学系应用化学专业 1997-2002 理学博士, 兰州大学化学系有机化学专业 (导师: 涂永强 院士) 2002-2007 博士后,法国国家科学研究中心,天然产物化学研究所(导师: 祝介平) 任职: 2007- 副教授(课题组长),北京大学 研究方向与兴趣: 1. 具有重要生物活性天然产物的全合成及仿生合成;

2. 生物活性天然产物的结构改造以及构效关系研究;

3. 有机合成新方法、新策略的研究. 获奖情况:

2010 Asian Core Program Lectureship Award

2009 新世纪优秀人才支持计划

2009 北京大学医学部优秀青年学者 2008-2009 教学优秀奖

2008 第十一届中国药学会-施维雅青年药物化学奖

2002 甘肃省科技进步奖, 一等奖(排名第五)

1997 兰州大学优秀毕业生

1997 张淑明奖学金 承担项目: 1. 2010.1-2012.12:国家自然科学基金委面上项目, Celogentins 的合成及 构效关系研究 . (20972007) 2. 2010.1-2013.12:国家自然科学基金委重点项目, 海绵 baculiferin 型新 生物碱探针对 HIV-1 Vif 和APOBEC3G 的靶向调控及作用机理研究 . (30930109/C180202) 3. 2010.1-2014.8:科技部 973, 具有重要生物活性的天然产物的化学合成 . (2010CB833200) 4. 2010.1-2012.12:教育部创新团队发展计划, 基于内源性物质的先导物发 现 . (IRT0902) 5. 2009.1-2011.12:国家自然科学基金委青年基金, 几种吲哚类生物碱的全 合成研究 . (20802005) 6. 2009.1-2011.12:教育部博士点新教师基金, Celogentin C 的合成研究 . (200800011055) 7. 2009.9-2010.09:中国科学院上海药物研究所新药研究国家重点实验室开放 研究课题, Celogentins 的全合成及构效关系研究 . 8. 2009.1-2009.12:兰州大学功能有机分子化学国家重点实验室开放课题, Celogentins 的全合成研究 . 9. 教育部留学回国人员科研启动基金, 杀鱼菌素类天然产物的全合成研究 . 10. 2008.1-2008.12:兰州大学功能有机分子化学国家重点实验室开放课题, , 几种 3,4-二取代吲哚类生物碱的全合成研究 . 11. 2007.9-2008.8:国家自然科学基金委主任基金, 杀鱼菌素类天然产物的全 合成研究 . (20842004) 12. 2007.11-2010.10:北京大学医学部、天然药物及仿生药物国家重点实验室 (引进人才基金) , 几种具有重要生物活性的吲哚类生物碱的全合成研究 . 论文及专著: 迄今为止已在国内外重要学术刊物上发表研究论文

40 篇. 独立课题组后: 40. Total Synthesis of (±)-Decursivine and (±)-Serotobenine: A Cascade Witkop Photocyclization/Elimination/O-Michael Addition Approach Hua Qin, Zhengren Xu, Yuxin Cui, Yanxing Jia* Angew. Chem. Int. Ed. 2011, 50, (online, DOI: 10.1002/anie.201100495). 39. Total Synthesis of (C)-Indolactam V Zhengren Xu, Fengying Zhang, Lihe Zhang, Yanxing Jia* Org. Biomol. Chem. 2011, 9, 2512C2517. 38. Total Synthesis of Lamellarins D, H, and R and Ningalin B Qingjiang Li, Jingqian Jiang, Aili Fan, Yuxin Cui, Yanxing Jia* Org. Lett. 2011, 13, 312C315. 37. Total Synthesis of Clavicipitic Acid and Aurantioclavine: Stereochemistry of Clavicipitic Acid Revisited Zhengren Xu, Weimin Hu, Qiang Liu, Lihe Zhang, Yanxing Jia* J. Org. Chem. 2010, 75, 7626C7635. 36. One-Pot AgOAc-Mediated Synthesis of Polysubstituted Pyrroles from Primary Amines and Aldehydes: Application to the Total Synthesis of Purpurone Qingjiang Li, Aili Fan, Zhiyao Lu, Yuxin Cui, Wenhan Lin, Yanxing Jia* Org. Lett. 2010, 12, 4066C4069. 35. Stereocontrolled and Efficient Total Synthesis of (C)-Stephanotic Acid Methyl Ester and (C)-Celogentin C Weimin Hu, Fengying Zhang, Zhengren Xu, Qiang Liu, Yuxin Cui, Yanxing Jia* Org. Lett. 2010, 12, 956C959. 34. Water-Controlled Regioselectivity of Pd-Catalyzed Domino Reaction Involving a CCH Activation Process: Rapid Synthesis of Diverse Carbo- and Heterocyclic Skeletons Zhiyao Lu, Chunmei Hu, Jiajie Guo, Jing Li, Yuxin Cui, Yanxing Jia* Org. Lett. 2010, 12, 480C483. 33. Artificial Transcription Factors which Mediate Double-Strand DNA Cleavage Chao Li, Chao Du, Hua Tian, Chao Jiang, Min Du, Yan Liu, Renzhong Qiao*, Yanxing Jia*, and Yufen Zhao* Chem. Eur. J. 2010, 16, 12935C12940. 32. Formal synthesis of semiaquilegin A Jing Li, Yong Jiang, Qingjiang Li, Qiang Xiao, Yanxing Jia*, Pengfei Tu* Tetrahedron Lett. 2010, 51, 1121C1123. 31. Palladium-Catalyzed Synthesis of Tryptamines and Tryptamine Homologues: Synthesis of Psilocin Chunmei Hu, Hua Qin, Yuxin Cui, Yanxing Jia* Tetrahedron 2009, 65, 9075C9080. 30. Efficient Total Synthesis of (C)-cis-Clavicipitic Acid Zhengren Xu, Qingjiang Li, Lihe Zhang, Yanxing Jia* J. Org. Chem. 2009, 74, 6859C6862. 29. Total Synthesis of (-)-Incarvilline and (-)-Incarvillateine Fengying Zhang, Yanxing Jia* Tetrahedron 2009, 65, 6840C6843. 28. Palladium-Catalyzed Indole and Azaindole synthesis by Direct Annulation of Electron-Poor o-Chloroanilines and Chloroaminopyridines with Aldehydes Zhengren Xu, Weimin Hu, Fengying Zhang, Qingjiang Li, Zhiyao Lü, Lihe Zhang, Yanxing Jia* Synthesis 2008, 3981C3987. 博士、博士后期间: 27. Total Synthesis of Complestatin (Chloropeptin II) Zhihui Wang, Michèle Bois-Choussy, Yanxing Jia, Jieping Zhu* Angew. Chem. Int. Ed. 2010, 49, 2018C2022. 26. Synthesis of Diastereomers of Complestatin, and Chloropeptin, High Substrate-dependent Atropstereoselectivity of Intramolecular Suzuki-Miyaura Reaction Yanxing Jia, Michèle Bois-Choussy, Jieping Zhu* Angew. Chem. Int. Ed. 2008, 47, 4167C4172. 25. Synthesis of DEFG Ring of Complestatin and Chloropeptin I: Highly Atropdiastereoselective Macrocyclization by Intramolecular Suzuki-Miyaura Reaction Yanxing Jia, Michèle Bois-Choussy, Jieping Zhu* Org. Lett. 2007, 9, 2401C2404. 24. Palladium-Catalyzed Enantioselective Domino Heck-Cyanation Sequence: Development and Application to the Total Synthesis of Physostigmine Artur Pinto, Yanxing Jia, Luc Neuville, Jieping Zhu* Chem. -A Eur. J. 2007, 13, 961C967. 23. Importance of the Structure of Vancomycin Binding Pocket in Designing Compounds Active Against Vancomycin-resistant Enterococci (VRE) Yanxing Jia, Michèle Bois-Choussy, Adriano Malabarba, Cristina Brunati, Jieping Zhu* J. Antibiotics. 2006, 59, 543C552. 22. Palladium-Catalyzed, Modular Synthesis of Highly Functionalized Indoles and Tryptophans by Direct Annulation of Substituted o-Haloanilines and Aldehydes Yanxing Jia, Jieping Zhu* J. Org. Chem. 2006, 71, 7826C7834. 21. A Novel Strategy for the Key Fully Substituted Cyclopentenedione Moiety of Madindolines via AlEt3-Promoted Tandem Reductive Rearrangement of ?-Hydroxy Epoxides Shuanhu Gao, Yanxing Jia, Xuezhi Zhao, Yongqiang Tu* Chin. J. Chem. 2006, 24, 595C597. 20. Design and Synthesis of Simple Macrocycles Active Against Va........