PDF《六味地黄丸联合银杏叶片对 2 型糖尿病 患者糖尿病并发症的...》

国际中医中药杂志2015年3月第37卷第3期Int J Trad Chin Med, March 2015, Vol.

37, No.3?213・? ・论著・ 六味地黄丸联合银杏叶片对

2 型糖尿病 患者糖尿病并发症的影响 吴亚平 付丽媛 郭琳 余江毅 马建华 【摘要】 目的 探讨六味地黄丸与银杏叶片联合应用对

2 型糖尿病 (type

2 diabetes mellitus, T2DM) 患者糖尿病并发症的影响. 方法 收集

2011 年3-9 月南京医科大学附属南京医院内分泌科收治的 T2DM 患者

78 例,按随机数字表法分为

2 组,每组

39 例.常规治疗组口服降糖药或胰岛素控制,中药治疗组 在常规治疗基础上加用六味地黄丸和银杏叶片.分别于治疗前,治疗后

12 个月、36 个月监测颈动脉内膜 中层厚度(intima-media thickness, IMT) 、双足振动感觉阈值(vibration perception threshold, VPT)及糖尿 病视网膜病等情况.结果 治疗后

12 个月,中药治疗组左足 VPT 明显低于常规治疗组[(13.98±4.38)V 比(18.70±2.43)V;

t=2.764,P=0.008].治疗后

36 个月,中药治疗组颈动脉 IMT[左侧:(0.70±0.10)mm 比(0.81±0.16)mm,t=3.120,P=0.003;

右侧:(0.73±0.12)mm 比(0.81±0.17)mm,t=2.286,P=0.026];

VPT[左足:(14.82±6.45)V 比(20.63±9.75)V,t=2.714,P=0.009;

右足:(16.73±7.10)V 比(20.73± 10.35)V, t=2.001, P=0.048], 以及糖尿病视网膜病发生率[35.9%(14/39)比53.8%(21/39);

χ2 =5.804, P=0.016]均明显低于常规治疗组.结论 六味地黄丸联合银杏叶片可有效减缓 T2DM 患者糖尿病并发症 的进展. 【关键词】 六味地黄丸;

银杏叶;

糖尿病,2 型;

糖尿病并发症 Effects of Liuwei-Dihuang Pills combined with Ginkgo Biloba Leaves Extract Tablets on complications of type

2 diabetes mellitus Wu Yaping* , Fu Liyuan, Guo Lin, Yu Jiangyi, Ma Jianhua. * Department of Endocrinology, Nanjing Hospital Affiliated to Nanjing Medical University, Nanjing 210006, China Corresponding author: Ma Jianhua, Email: [email protected] 【Abstract】 Objective To investigate the effects of Liuwei-Dihuang Pills combined with Ginkgo Biloba Leaves Extract Tablets on diabetic complications in patients with type

2 diabetes mellitus (T2DM). Methods Seventy-eight patients with T2DM were randomized into a TCM treatment group and a conventional treatment group by random number table method,

39 in each group. The patients in the conventional treatment group were regularly using antihyperglycemic drugs or insulin. On the basis of conventional treatment group, the patients in the TCM treatment group were additionally treated with Liuwei-Dihuang Pills and Ginkgo Biloba Leaves Extract Tablets. Intima-media thickness (IMT) of internal carotid artery, vibration perception threshold (VPT) and diabetic retinopathy in both groups were detected before the treatment,

12 and

36 months after the treatment. Results The VPT in the left foot

12 months after the treatment in the TCM treatment group were significantly lower than that in the conventional treatment group (13.98 ± 4.38 V vs. 18.70 ± 2.43 V;

t=2.764, P=0.008). IMT of internal carotid artery (left: 0.81 ± 0.16 mm vs. 0.70 ± 0.10 mm, t=3.120, P=0.003;

right: 0.81 ± 0.17 mm vs. 0.73 ± 0.12 mm, t=2.286, P=0.026), VPT (left foot: 14.82 ± 6.45 V vs. 20.63 ± 9.75 V, t=2.714, P=0.009;

right foot: 16.73 ± 7.10 V vs. 20.73 ± 10.35 V, t=2.001, P=0.048) and incidence of diabetic retinopathy (35.9% vs. 53.8%;

χ2 =5.804, P=0.016)

36 months after the treatment in the TCM treatment group were DOI: 10.3760/cma.j.issn.1673-4246.2015.03.006 基金项目:国家十一五支撑计划(2006BAI04A03-1) 作者单位:210006 南京医科大学附属南京医院(南京市第一医院)内分泌科(吴亚平、付丽媛、郭琳、马建华) ;