PDF《导师简介》

导师简介 姓名:陈世稆 职称:教授, 博士生导师 电子邮件:shlchen@bit.

edu.cn 主要经历: 2012/07 C 至今,北京理工大学,化学学院,教授;

2010/10 C 2012/07,北京理工大学,化学学院,副教授;

2009/04 C 2010/09,瑞典斯得哥尔摩大学,物理系,博士后;

2005/11 C 2009/02,瑞典皇家工学院,生物技术学院, 生物技术 博士;

2004/09 C 2008/01,北京师范大学,化学学院, 物理化学 博士;

2001/09 C 2004/07,北京师范大学,化学系, 分析化学 硕士;

1997/09 C 2001/07,北京师范大学,化学系, 化学教育 学士 研究方向:生物酶催化反应机理的理论研究 主要研究兴趣在计算生物学方面,尤其是金属酶的催化反应机理.运用理 论化学手段,主要是密度泛函理论(DFT)方法,研究各种金属酶的催化反应机 理. 研究对象包括多种过渡金属酶, 如含镍金属酶(Methyl-Coenzyme M Reductase, CO dehydrogenase 等), 维生素B12 依赖酶(methionine synthase 和Methylmalonyl-CoA mutase), 血红素依赖酶(chlorite mutase) , 双锌酶(Phosphotriesterase, Glyoxalase II, alkaline phosphatase, and Aminopeptidase from Aeromonas proteolytica), 等等. 承担课题: 主持了

3 项国家自然科学基金项目.参加一项科技部

973 项目课题. 入选

2015 年北京市科技新星计划. 获奖情况: 2009年, 获得中国国家留学基金管理委员会颁发的 2008年度国家优秀自费留学 生奖 .

2011 年,获北京理工大学

2010 年度 优秀青年教师 奖. 发表论文: [1] Cui-Lan Lan and Shi-Lu Chen*, The Decarboxylation of α,β-Unsaturated Acid Catalyzed by Prenylated FMN-Dependent Ferulic Acid Decarboxylase and the Enzyme Inhibition, The Journal of Organic Chemistry, 2016, 81(19), 9289C9295. [2] Jian-Nan Ji and Shi-Lu Chen*, μ3-Oxo stabilized by three metal cations is a sufficient nucleophile for enzymatic hydrolysis of phosphate monoesters, Dalton Trans., 2016, 45, 2517C2522. [3] Qun Liu, Ze-Sheng Li, and Shi-Lu Chen*, Metal-Embedded Graphene as Potential Counter Electrode for Dye-Sensitized Solar Cell, Ind. Eng. Chem. Res., 2016,

55 (2), 455C462. [4] Shi Tang*, You-Lin Deng, Jie Li, Wen-Xin Wang, Ying-Chun Wang, Zeng-Zeng Li, Li Yuan, Shi-Lu Chen*, and Rui-Long Sheng, Aerobic oxidative cyclization of benzamides via meta-selective CCH tert-alkylation: rapid entry to 7-alkylated isoquinolinediones, Chem. Commun., 2016, 52, 4470-4473. [5] Rong-Zhen Liao*, Shi-Lu Chen, Per E. M. Siegbahn, Unraveling the Mechanism and Regioselectivity of the B12-Dependent Reductive Dehalogenase PceA, Chemistry - A European Journal, 2016, 22(35), 12391C12399. [6] Hai-Mei Zhang and Shi-Lu Chen*, Include Dispersion in Quantum Chemical Modeling of Enzymatic Reactions: The Case of Isoaspartyl Dipeptidase, J. Chem. Theory Comput., 2015, 11(6), 2525-2535. [7] Bo Zou, Liang Hao, Lin-Yuan Fan, Zhi-Ming Gao, Shi-Lu Chen*, Hui Li*, Chang-Wen Hu*, Highly efficient conversion of CO2 at atmospheric pressure to cyclic carbonates with in situ-generated homogeneous catalysts from a copper-containing coordination polymer, Journal of Catalysis, 2015, 329, 119-129. [8] Shi-Lu Chen*, Chemical Empiricism 2.0 at Age of Big Data: Large-scale Prediction of Reaction Pathways Based on Bond Dissociation Energies, Chinese J. Chem. Phys., 2015, 28(6), 674C680. [9] Nan Guo, Jin-Yi Zhong*, Shi-Lu Chen*, Jing-Quan Liu, Qi Min, Rui-Xue Shi, Experimental and theoretical studies of hydrolysis of nerve agent sarin by binuclear zinc biomimetic catalysts, Chemical Physics, 2015, 457, 70-77. [10] Li-Na Yang, Shi-Lu Chen*, Ze-Sheng Li*, How does the silicon element perform in JD-dyes: a theoretical investigation, J. Mater. Chem. A, 2015, 3, 8308C8315. [11] Xiaopeng Wang, Lixia Wang, Fei Zhao, Chuangang Hu, Yang Zhao, Zhipan Zhang*, Shilu Chen*, Gaoquan Shi and Liangti Qu*, Monoatomic-thick graphitic carbon nitride dots on graphene sheets as an efficient catalyst in the oxygen reduction reaction, Nanoscale, 2015, 7, 3035C3042. [12] Li-Na Yang, Hong-Yan Zhou, Ping-Ping Sun, Shi-Lu Chen*, Ze-Sheng Li*, A Promising Candidate with D-A-A-A Architecture as an Efficient Sensitizer for Dye-Sensitized Solar Cells, ChemPhysChem, 2015, 16, 601C606. [13] Rong-Zhen Liao*, Shi-Lu Chen, Per E. M. Siegbahn, Which Oxidation State Initiates Dehalogenation in the B12-Dependent Enzyme NpRdhA: CoII , CoI , or Co0 , ACS Catalysis, 2015, 5, 7350C7358. [14] Xiaoyu Ma, Bo Zou, Minhua Cao*, Shi-Lu Chen*, Changwen Hu*, Nitrogen-doped porous carbon monolith as a highly efficient catalyst for CO2 conversion, J. Mater. Chem. A, 2014, 2, 18360C18366. [15] Shi-Lu Chen*, Margareta R. A. Blomberg, Per E. M. Siegbahn*, An Investigation of Possible Competing Mechanisms for Ni-containing Methyl-Coenzyme M Reductase, Phys. Chem. Chem. Phys., 2014, 16, 14029-14035. [16] Li-Na Yang, Zhu-Zhu Sun, Quan-Song Li, Shi-Lu Chen*, Ze-Sheng Li*, Thomas A. Niehaus, Unsymmetrical Squaraine Dye Containing Dithieno[3,2-b:2′,3′-d]pyrrole as a π-spacer: a Potential Photosensitizer for Dye-Sensitized Solar Cells, Journal of Power Sources, 2014, 268, 137-145. [17] Shi-Lu Chen*, Rong-Zhen Liao*, Phosphate Monoester Hydrolysis by Trinuclear Alkaline Phosphatase;