PDF《Induced Plasticity》

12 h/12 h light/dark cycle and had ad libitum access to food and water. Rats that received cannula or catheter surgeries were single-housed following surgery to prevent cage-mates from tampering with catheter/cannula implants. Mice and rats were housed in a humidity and temperature-controlled, Association for As- sessment and Accreditation of Laboratory Animal Care-accredited, ani- mal facility at the University of Miami Miller School of Medicine. All experiments were approved by the Institutional Animal Care and Use Committee before experimentation and conducted according to specifi- cations of the National Institutes of Health as outlined in the Guide for the Care and Use of Laboratory Animals. Drug treatments Cocaine HCl (National Institute on Drug Abuse) was dissolved in 0.9% sterile saline. Mice and rats received one injection (intraperitoneally) of saline or cocaine (10 mg/kg for rats and

20 mg/kg for mice) per day for

10 d, and were killed at multiple time points........