PDF《in restoration》

26 April 2010;

revised

27 November 2010;

accepted

6 December 2010;

published online

18 January

2011 Correspondence: Dr P Svenningsson, Center of Molecular Med- icine, Department of Physiology and Pharmacology, Nanna Svartz va ¨g 2, Karolinska Institute, Stockholm SE-171 77, Sweden. E-mail: [email protected] Molecular Psychiatry (2012) 17, 173C184 &

2012 Macmillan Publishers Limited All rights reserved 1359-4184/12 www.nature.com/mp pathways.21,22 In particular, the MAPK pathway is involved in behavioral effects of antidepressants and an important modulator of ionotropic receptor signal- ing, structural remodeling and consolidation of fear memories.23C25 Synaptic activation of MAPK induces, via CREB and Elk-1, expression of activity-related cytoskeletal-associated protein (Arc/Arg 3.1).23,26C28 Arc expression is induced by long-term potentiation- inducing stimuli, requiring NMDAR,27,29 involved in synaptic memory consolidation and enriched in hippocampal dendritic spines where its activation is required for acquisition of contextual and spatial learning.26,30,31 Arc expression is also activated by several other mechanism(s), including BDNF,28 protein kinase A,30 and pertussis-induced inhibition of Gi-mediated signaling.32 Accordingly, blockade of 5- HT1AR augments the effect of an acute dose........