PDF《ORIGINAL ARTICLE》

151 (58%) of the

260 MM patients. IGH translocations and RB deletions were observed in

95 (36%) and

109 (42%) out of the

260 patients, respectively;

whereas P53 deletions were present in 8.5% (22/260) of patients. The distribution of IGH transloca- tions according to 14q32 partners were: t(11;

14) in 13% (34/260 patients), t(4;

14) in 11% (29/260 patients), t(14;

16) in 3% (7/260 patients) and IGH rearrangements with other unknown partners in 10% (25/260 patients). Correlations between chromosomal abnormalities A signi?cant association between t(4;

14) and RB deletions was observed. Thus, 79% of patients with t(4;

14) had RB deletions vs 37% of patients without t(4;

14) (Po0.001). However, no correlation was found between this translocation and P53 deletions (Table 2). In contrast, t(11;

14) was signi?- cantly associated with P53 deletions but not with RB deletions (Table 2). Translocations involving 16q and other unknown IGH partners did not correlate with RB or P53 deletions. Finally, a signi?cant association was observed between P53 and RB deletions (P ? 0.009) (Table 2). Association between chromosomal abnormalities and clinical and biological parameters Overall, IGH translocations and RB deletions were signi?cantly more frequent in younge........