PDF《康柏西普联合玻璃体切割术治疗脉络膜脱离后增生性玻 璃体视...》

・临床论著・ 康柏西普联合玻璃体切割术治疗脉络膜脱离后增生性玻 璃体视网膜病变 史秀贞1 ,张摇 丽2 ,李清林3 基金项目:甘肃省卫生行业科研计划项目(No.

GSWSKY-2014- 13);

国家自然科学基金项目(No. 81360554) 作者单 位:1 (252300 ) 中国山东省聊城市光明眼科医院;

2 (100176) 中国北京市, 北京同仁医院眼科屈光中心;

3 (730050)中国甘肃省兰州市,甘肃中医药大学中医临床学院 作者简介:史秀贞,毕业于泰山医学院,本科,主治医师,研究方 向:白内障、眼底病. 通讯作者:张丽,毕业于哈尔滨医科大学,硕士,主治医师,研究 方向:眼视光学. qihaian@ qq. com 收稿日期: 2018-06-10 摇摇修回日期: 2018-11-08 Clinical efficacy of Conbercept combined with vitrectomy for proliferative vitreoretinopathy after choroidal detachment Xiu-Zhen Shi1 , Li Zhang2 , Qing-Lin Li3 Foundation items: Gansu Province Health Industry Research Project ( No. GSWSKY -

2014 -

13 );

National Natural Science Foundation of China (No. 81360544)

1 Liaocheng Guangming Ophthalmology Hospital, Liaocheng 252300, Shandong Province, China;

2 Refractive Surgery Center, Beijing Tongren Hospital, Beijing 100176, China;

3 Clinical School of Traditional Chinese Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730050, Gansu Province, China Correspondence to:Li Zhang. Refractive Surgery Center, Beijing Tongren Hospital, Beijing 100176, China. qihaian@ qq. com Received:2018-06-10摇摇Accepted:2018-11-08 Abstract SAIM: To evaluate the clinical effect of Conbercept combined with vitrectomy in the treatment of proliferative vitreoretinopathy ( PVR ) after choroidal detachment. SMETHODS: From January

2015 to January 2018,

66 eyes of

64 patients with PVR were treated in our hospital. All the patients were randomly divided into control group (32 cases,

34 eyes) and observation group (32 cases,

32 eyes ). The control group was treated with routine vitreoretinal surgery. The observation group was treated with routine vitreoretinal surgery combined with intravitreal injection of conbercept. The clinical efficacy, operative duration, intraoperative bleeding, incidence of iatrogenic holes and the best corrected visual acuity (BCVA), subfoveal choroidal thickness before and after treatment were compared between the two groups. SRESULTS: After

3 - 6mo follow- up, the total effective rate in the observation group (94%) was significantly higher than that in the control group (74%), and the difference was statistically significant ( P < 0.

05 ). The duration of operation in the observation group was significantly shorter than that in the control group, and the incidence of intraoperative hemorrhage and iatrogenic hiatus were significantly lower in the observation group than in the control group ( P< 0. 05). Before treatment, there was no significant difference in serum VEGF level and bFGF content between the two groups ( P > 0. 05). After treatment, the above indexes were lower than those before treatment. The levels of serum VEGF and bFGF in the observation group were significantly lower than those in the control group ( P < 0郾05 ). Before treatment, there was no significant difference in the thickness of subfoveal choroid and BCVA between the two groups (P> 0. 05). The BCVA of the two groups was significantly higher than that before treatment. The thickness of subfoveal choroid in the observation group was significantly lower than that before surgery ( P < 0郾05 ), and the thickness of the subfoveal choroid in the observation group was significantly lower than that in the control group ( P