PDF《徐萍 教授》

激酶抑制剂类抗病毒药物和抗肿瘤药物研究;

药物设计、药物合成 及构效关系研究;

拟肽类和肽核酸类组合合成方法学研究. 近三年负责科研课题

1、重大心血管疾病相关GPCR新药物靶点的基础研究― ― 内源性血管活性物质及其GPCR在动脉粥样硬化中的作用,国 家重点基础研究发展计划(973计划),课题骨干, 2012-2016

2、MEK抑制剂类新型抗病毒药物研究(国家自然科学基金),2012.1-2015.12

3、新型抗肿瘤药物蛋白酶体抑制剂的设计、合成及优化(北京市自然科学基金),2011.1-2013.12

4、新型抗肿瘤药物蛋白酶体抑制剂的设计、合成及优化(方正创新药物研究基金),2011.1-2012.12

5、ERK信号通路不同激酶及亚型在病毒复制中整合作用研究(863计划重点课题),2007-2010(副组长)

6、抗老年痴呆药物b-分泌酶抑制剂的设计、合成及优化(国家自然科学基金),2008.1-2010.12

7、新型抗肿瘤药物蛋白酶体抑制剂的设计、合成及优化(国家自然科学基金),2008.1-2010.12 代表性论文、专利 1. 发明名称:具有蛋白酶体抑制功能的化合物及其制备方法与应用.发明人:徐萍,付翌秋,邹晓民.专利号:ZL

2006 1 0012149.7 2. Gang Fu, Robert J. Doerksen*, Ping Xu*. Assignment of absolute configuration of sulfinyl dilactones: Optical rotations and 1H NMR experiment and DFT calculations. Journal of Molecular Structure. 2011, 987: 166-173. 3. Yan Niu, Yuehua Wang, Xiaomin Zou, Xiaoming Yang, Chao Ma, Yang Lü, Bo Zhou, Yue Yuan, Guanhua Du and Ping Xu*. Synthesis and preliminary evaluation of peptidomimetic inhibitors of human β-secretase. European Journal of Medicinal Chemistry. 2010, 45(5): 2089-2094. 4. Yue Yuan, Xiao-Min Zou, Yan Niu, Feng-Rong Xu, Ke Mou, Bo Zhou, Chao Wang, Yong-Jian Li, Guan-Yu Yang and Ping Xu*. Synthesis of acyclic analogs of Syringolin A as potential 20S proteasome inhibitors. Journal of Chinese Pharmaceutical Sciences. 2010, 19(6): 423-435. 5. Wenjing Chen, Ke Mou, Bo Xu, Xiaomei Ling*, Jingrong Cui, Ping Xu*. Capillary electrophoresis for screening of 20S proteasome inhibitors. Analytical Biochemistry. 2009,

394 (1): 62C67. 6. Ke Mou, Bo Xu, Chao Ma, Xiaoming Yang, Xiaomin Zou, Yang Lü, Ping Xu*. Novel CADD-based Peptidyl Vinyl Ester Derivatives as Potential Proteasome Inhibitors. Bioorganic &

Medicinal Chemistry Letters. 2008, 18(8): 2198-2202. 7. Yiqiu Fu, Bo Xu, Xiaomin Zou, Chao Ma, Xiaoming Yang, Ke Mou, Gang Fu, Yang Lü, Ping Xu*. Design and Synthesis of A Novel Class of Furan-based Molecules as Potential 20S Proteasome Inhibitors. Bioorganic &

Medicinal Chemistry Letters. 2007, 17(4): 1102-1106. 8. Xiaoming Yang, Xiaomin Zou, Yiqiu Fu, Ke Mou, Gang Fu, Chao Ma and Ping Xu*. Synthesis of β-Secretase Inhibitors Containing a Hydroxyethylene Dipeptide Isostere. Synthetic Communications. 2007, 37(1): 9-24. ........