PDF《基本信息 姓名 徐美娟》

个人免冠近照 基本信息 姓名 徐美娟 职称 副教授 学历/学位 研究生/博士 联系电话 0510-85910886 电子邮箱 xumeijuan@jiangnan.

edu.cn 个人简介 长期从事微生物系统代谢工程与酶工程的研究 ,主要承担《微生物学》和《微生物遗传育种学》课程的讲授工作.近年来 共发表高水平研究论文40余篇,累计影响因子>110,他引120余次;

申请发明专利40余项,授权发明专利20项,其中授权 国际PCT发明专利1项;

主持包括863计划子课题、国家自然科学基金、江苏省自然科学基金等在内的省部级科研项目 6项;

获得中国轻工业联合会技术发明奖二等奖 1项(2016,3/6),指导学生获全国大学生生命科学创新创业大赛一等奖 1项,获 校级优秀本科毕业论文1项. 学习工作经历(自本科填起) 2001.9-2005.6 河北农业大学,生物工程专业,工科学士 2005.9-2008.7 江南大学, 微生物学专业,理学硕士 2008.9-2012.3 江南大学,发酵工程专业,工学博士 2012.3-2013.9 江南大学,生物工程学院,讲师 2013.10- 至今 江南大学,生物工程学院, 副教授 其中: 2016.11-2017.11 美国 康奈尔大学(Cornell University),营养科学系,国家公派访问学者 主要代表性成果:

一、论文(论著)发表情况 近5年在Metabolic Engineering、Amino Acids 等期刊发表论文50余篇,其中以第一/通讯作者发表SCI论文12篇. 其中代表性文章如下: 1. Shu, Q., Xu, M*, Li, J, Yang, T, Zhang, X, Xu, Z, Rao, Z*. Improved l-ornithine production in Corynebacteriumcrenatum by introducing an artificial linear transacetylation pathway. J Ind Microbiol Biotechnol, 2018. 45(6): p. 393-404. 2. Zhou J, Wang Y, Chen J, Xu M*, Yang T, Zheng J, Zhang X, Rao Z*. Rational engineering of Bacillus cereus leucine dehydrogenase towards α-keto acid reduction for improving unnatural amino acid production. Biotechnol J, 2018, 0(ja): p. 1800253. 3. Zhang J, Xu M*, Ge X, Zhang X, Yang T, Xu Z, Rao Z*. Reengineering of the feedback-inhibition enzyme N-acetyl-l-glutamate kinase to enhance l-arginine production in Corynebacteriumcrenatum. J Ind Microbiol Biotechnol,2017, 44(2): 271-283. 4. Zhang, J, Xu M*, Zhang X, Yang T, Xu Z, Rao Z*. Engineering of N-Acetyl-L-glutamate kinase from Corynebacterium glutamicum toward improved catalytic efficiency and thermostability. J Mol Catal B: Enzymatic,2016, 133: p. S360-S370. 5. Xu M, Qin J, Rao Z*, You H, Zhang X, Yang T, Xu Z*. Effect of Polyhydroxybutyrate(PHB) storage on l-arginine production in recombinant Corynebacteriumcrenatum using coenzyme regulation. Microb Cell Fact, 2016, 15(1): 15. 6. Man Z#, Xu M#, Rao Z*, Guo J, Yang T, Zhang X, Xu Z. Systems pathway engineering of Corynebacterium crenatum for improved L-arginine production. Sci Rep. 2016;

6:28629. 7. Meijuan Xu, Zhiming Rao*, Wenfang Dou, Juan Yang, Jian Jin, Zhenghong Xu*. Site-directed mutagenesis and feedback- resistant N-acetyl-L-glutamate kinase (NAGK) increase Corynebacterium crenatum L-arginine production. Amino Acids. 2012, 43(1):255-266. 8. Meijuan Xu, Zhiming Rao*, Juan Yang, Haifeng Xia, Wenfang Dou, Jian Jin, Zhenghong Xu*. Heterologous and homologous expression of the arginine biosynthetic argC~H cluster from Corynebacterium crenatum for improvement of L-arginine production. J Ind Microbiol Biotechnol. 2012, 39(3):495-502. 9. Meijuan Xu, Zhiming Rao*, Haifeng Xia, Wenfang Dou, Jian Jin, Zhenghong Xu*. Site-directed mutagenesis studies on the L- arginine binding sites of feedback inhibition in N-acetyl-L-glutamate kinase (NAGK) from Corynebacterium glutamicum. Curr Microbiol, 2012, 64: 164-172. 10. Meijuan Xu, Zhiming Rao*, Wenfang Dou, Zhenghong Xu*. The Role of ARGR Repressor Regulation on L-arginine Production in Corynebacteriumcrenatum. Appl Biochem Biotechnol, 2013, 170(3):587-597. 11. Meijuan Xu, Zhiming Rao*, Juan Yang, Wenfang Dou, Zhenghong Xu*. The Effect of a LYSE Exporter Overexpression on L- Arginine Production in Corynebacterium crenatum. Curr Microbiol. 2013,67:271-278. 12. Meijuan Xu, Rongzhen Zhang, Xiangyu Liu, Jingsong Shi, Zhenghong Xu, Zhiming Rao*. Improving the acidic stability of a β-