PDF《Supporting Information》

1 H NMR (400 MHz, CDCl3) δ 8.38 (dd, J = 4.0, 0.8 Hz, 1H), 7.90 (br, 1H), 7.69 (td, J = 8.0, 1.6 Hz, 1H), 7.44 (d, J = 8.0 Hz, 1H), 7.29 (dd, J = 8.4, 1.2 Hz, 2H), 7.24 C 7.19 (m, 3H), 7.17 - 7.13 (m, 4H), 2.41 (s, 3H), 1.86 (s, 6H);

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13 C NMR (100 MHz, CDCl3) δ 167.47, 164.35, 147.56, 141.44, 137.11, 136.94, 136.23, 131.75, 131.06, 130.44, 129.83, 129.19, 126.70, 121.88, 119.59, 57.44, 27.46, 19.45;

HRMS (EI-TOF) calcd for C22H22N2OS (M+ ): 362.1453, found: 362.1458. 6-Phenyl-2-(phenylthio)-N-(2-(Pyridin-2-yl)propan-2-yl)benzamide 3b

1 H NMR (400 MHz, CDCl3) δ 8.33 (d, J = 4.0 Hz, 1H), 7.63 (br, 1H), 7.57 (td, J = 8.4, 1.6 Hz, 1H), 7.52 (d, J = 6.8 Hz, 2H), 7.44 (d, J = 7.2 Hz, 2H), 7.34 - 7.27 (m, 6H), 7.24 (d, J = 8.0 Hz, 2H), 7.19 (d, J = 7.6 Hz, 2H), 7.08 (dd, J = 6.4, 4.8 Hz, 1H), 1.56 (s, 6H);

13 C NMR (100 MHz, CDCl3) δ 166.74, 164.23, 147.40, 140.63, 140.15, 139.26, 136.94, 135.69, 134.66, 132.16, 130.72, 129.34, 129.22, 129.15, 128.68, 128.17, 127.55, 127.45, 121.67, 119.44, 57.31, 27.07;

HRMS (EI-TOF) calcd for C27H24N2OS (M+ ): 424.1609, found: 424.1603. 6-trifluoromethyl-2-(phenylthio)-N-(2-(pyridin-2-yl)propan-2-yl)benzamide 3c S8

1 H NMR (400 MHz, CDCl3) δ 8.43 (br, 1H), 8.40 (d, J = 4.8 Hz, 1H), 7.72 (td, J = 8.0, 1.6 Hz, 1H), 7.55 -7.53 (m, 1H), 7.45 (d, J = 8.4 Hz, 1H), 7.42 (dd, J = 8.1, 1.6 Hz, 2H), 7.34 C 7.28 (m, 5H), 7.17 (dd, J = 7.2, 4.8 Hz, 1H), 1.92 (s, 6H);

13 C NMR (100 MHz, CDCl3) δ 164.46, 164.12, 147.37, 137.66, 137.30, 137.16, 135.06, 134.43, 132.76, 129.58, 129.23, 128.35, 128.11, 124.62 (q, J = 4.9 Hz), 123.71 (q, J = 272.8 Hz), 122.01, 119.62, 57.70, 27.10;

HRMS (EI-TOF) calcd for C22H19F3N2OS (M+ ): 416.1170, found: 416.1174. 4,6-Dimethyl-2-(phenylthio)-N-(2-(pyridin-2-yl)propan-2-yl)benzamide 3d

1 H NMR (400 MHz, CDCl3) δ 8.36 (d, J = 4.0 Hz, 1H), 7.82 (br, 1H), 7.67 (td, J = 8.0, 1.6 Hz, 1H), 7.43 (d, J = 8.0 Hz, 1H), 7.26 (d, J = 7.2 Hz, 2H), 7.21 (t, J = 8.0 Hz, 2H), 7.14 C 7.10 (m, 2H), 6.99 (d, J = 13.6 Hz, 2H), 2.38 (s, 3H), 2.25 (s, 3H), 1.83 (s, 6H);

13 C NMR (100 MHz, CDCl3) δ 167.67, 164.38, 147.53, 139.17, 139.09, 137.38, 137.04, 136.10, 131.90, 130.96, 130.92, 129.90, 129.11, 126.40, 121.80, 119.56, 57.36, 27.43, 21.15, 19.38;

HRMS (EI-TOF) calcd for C23H24N2OS (M+ ): 376.1609, found: 376.1609. 5-Methyl-2-(phenylthio)-N-(2-(pyridin-2-yl)propan-2-yl)benzamide 3e

1 H NMR (400 MHz, CDCl3) δ 8.43 (dd, J = 4.0, 0.8 Hz, 1H), 8.34 (br, 1H), 7.66 (td, J = 8.0, 1.6 Hz, 1H), 7.52 (d, J = 0.8 Hz, 1H), 7.38 (d, J = 8.0 Hz, 1H), 7.26 C 7.17 (m, 6H), 7.16 C 7.13 (m, 2H), 2.36 (s, 3H), 1.77 (s, 6H);

13 C NMR (100 MHz, CDCl3) δ 167.15, 164.47, 147.75, 139.30, 138.02, 137.03, 136.66, 133.76, 131.34, 130.18, 129.83, 129.29, 129.12, 126.77, 121.80, 119.50, 57.48, 27.52, 21.07;

HRMS (EI-TOF) calcd for C22H22N2OS (M+ ): 362.1453, found: 362.1456. S9 5-trifluoromethyl-2-........