PDF《Supplementary Figures》

77 37 WT

21528 374

433 P1.113 f

77 37 WT

19376 398

457 P1.114 f

4 38 WT

20625 350

401 P1.115 f

77 37 WT

10316 365

432 P1.116 m

14 34 WT

16286 359

428 P1.117 m

179 42 A20IEC-KO

15964 369

416 P1.118 f

77 37 A20IEC-KO

17595 357

403 P1.119 m

106 37 A20IEC-KO

17617 362

421 P1.120 m

179 42 A20IEC-KO

17332 350

399 P1.121 m

286 40 A20IEC-KO

20879 379

430 P1.122 m

179 42 A20myel-KO

13019 271

306 P1.123 m

14 34 A20myel-KO

14657 334

370 P1.124 f

4 27 A20myel-KO

14547 311

376 P1.125 m

106 37 A20myel-KO

12070 325

365 P1.126 m

106 37 A20myel-KO

12071 275

326 P1.127 m

286 40 A20myel-KO

10992 358

425 P1.128 m

179 42 A20IEC/myel-KO

13237 332

371 P1.129 m

286 40 A20IEC/myel-KO

8105 302

331 P1.130 m

179 42 A20IEC/myel-KO

22499 277

312 P1.131 f

4 38 A20IEC/myel-KO

13806 303

336 P1.132 f

77 37 A20IEC/myel-KO

15205 341

404 P1.133 m

106 37 A20IEC/myel-KO

13399 303

348 Supplementary Table 1. Gut microbiota analysis by 16S rDNA pyrosequencing of cohoused wild-type (WT), A20IECCKO , A20myel-KO and A20IEC/myel-KO mice. Caecal samples ID, donor mouse metadata (gender, age, cage and genotype), number of sequenced reads after quality control (QQ Reads), and microbiota richness indexes: observed number of species after rarefaction (Obs) and estimated richness (Chao1). Genotypes Anosim R stat Anosim p-value Permutations Community distance (Bray-Curtis index) WT vs A20IEC-KO 0.10 0.240

999 WT vs A20myel-KO 0.44 0.013 *

999 WT vs A20IEC/myel-KO 0.55 0.005 **

999 A20myel-KO vs A20 IEC/myel-KO 0.20 0.048 *

999 Community distance accounting bacterial relatedness (weighted UniFrac) WT vs A20IEC-KO -0.02 0.454

999 WT vs A20myel-KO 0.10 0.190

999 WT vs A20IEC/myel-KO 0.28 0.011 *

999 A20myel-KO vs A20 IEC/myel-KO -0.02 0.403

999 * p