PDF《肝癌基因调控网络研究进展》

刘湘琼 等/肝癌基因调控网络研究进展 Chinese Journal of Biotechnology http://journals.

im.ac.cn/cjbcn October 25, 2016, 32(10): 1322?1331 DOI: 10.13345/j.cjb.160045 ?2016 Chin J Biotech, All rights reserved Received: January 19, 2016;

Accepted: March 3,

2016 Supported by: National Natural Science Foundation of China (Nos. 81402581, 31301092). Corresponding author: Yong Lin. Tel: +86-21-55271081;

E-mail: [email protected] 国家自然科学基金 (Nos. 81402581, 31301092) 资助.

1322 生物工程学报肝癌基因调控网络研究进展 刘湘琼 1,3 ,连保峰 2,3 ,林勇

1 1 上海理工大学 医疗器械与食品学院,上海

200093 2 上海交通大学 附属第一人民医院,上海

200240 3 上海生物信息技术中心,上海

201203 刘湘琼, 连保峰, 林勇. 肝癌基因调控网络研究进展. 生物工程学报, 2016, 32(10): 1322C1331. Liu XQ, Lian BF, Lin Y. Gene regulatory network of hepatocellular carcinoma: a review. Chin J Biotech, 2016, 32(10): 1322C1331. 摘要:肝癌 (Hepatocellular carcinoma,HCC) 是我国常见的恶性肿瘤之一.肝癌基因调控网络 (HCC regulatory network, HCC GRN) 是研究肝癌分子机制的重要途径之一, 其节点包括肝癌相关的分子, 如miRNA、 TF 等,网络的边由节点间相互作用关系构成.基于不同类型的数据构建的肝癌基因调控网络其类型及特征各 有不同.综合近年来肝癌基因调控网络研究发现,由TF 与miRNA 构建的肝癌转录调控网络更能揭露肝癌关 键基因, 反映关键基因在调控网络中的扰动情况. 整合基因变异信息与调控网络成为研究肝癌基因调控网络的 趋势,但相应的研究几乎是空白的.本文从 HCC GRN 的数据来源、分类及特征,及各类型调控网络的近年研 究情况等方面进行综述, 并结合相关研究工作对肝癌基因调控网络研究现状进行分析与讨论, 对前景进行展望, 为这一领域研究工作提供参考. 关键词: 肝癌,基因调控网络,转录调控网络,基因变异 Gene regulatory network of hepatocellular carcinoma: a review Xiangqiong Liu1,3 , Baofeng Lian2,3 , and Yong Lin1

1 School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China

2 Affiliated First People'

s Hospital, Shanghai Jiaotong University, Shanghai 200240, China

3 Shanghai Center for Bioinformation Technology, Shanghai 201203, China Abstract: Hepatocellular carcinoma (HCC) is one of the common malignant tumors. HCC gene regulatory network (HCC 综述刘湘琼 等/肝癌基因调控网络研究进展 ?:010-64807509 :[email protected]

1323 GRN), whose nodes consist of genes, miRNAs or TFs and whose edges consist of interaction relationships of nodes, is one of the important ways to study molecular mechanism of HCC. Based on various experimental data, types of HCC GRNs could be conducted such as TF-miRNA regulatory network. Integrating the studies of HCC GRN, TF-miRNA transcriptional regulatory network performs better in identifying core genes which play important roles in network disturbances. It is a trend that gene variations and transcriptional regulatory networks should be combined, however the corresponding research is almost blank. This review summarizes the source of HCC data sources, the classification, character, and research program of HCC GRN. Finally, according to present analysis and discussion of progress and research status of HCC GRN, we provide a useful reference for researchers. Keywords: hepatocellular carcinoma, gene regulatory network, transcriptional regulatory network, gene variation 原发性肝癌(Hepatocellular carcinoma, HCC) 简称肝癌, 是我国常见恶性肿瘤之一, 在 全球频繁发生癌症的死亡率中排第