PDF《韩立峰中医药研究院导师介绍》

中医药研究院导师介绍 导师姓名 韩立峰 性别 男 职称 高级实验师 出生年月 1983.

2 导师类别 硕导 导师学位 博士 联系电话

13702133290 E-mail [email protected] 招生要求 有较强的独立思考及动手能力 研究方向 中药化学、中药分析 简介 教育经历: 2011/9 - 2014/6,天津中医药大学,中药学,博士 2013/7 - 2014/5,意大利佛罗伦萨大学,访问学者 2005/9 - 2008/6,天津中医药大学,中药学,硕士 2000/9 - 2004/6,天津医科大学,药物制剂,学士 科研情况:入选天津市教委十二五优青教师,主持或参与科研课题

10 余项,目前负责课题 如下:

1 国家自然科学基金重点项目,经典方剂二至丸补益肝肾的生物学基础研究(81630106) 、 2017/01-2021/12,负责二至丸化学成分分离鉴定、质量控制研究.

2 国家中医药管理局中医药行业科研专项, 临床常见中药朱砂、 补骨脂、 决明子的配伍减 "毒" 研究(2015050) 、2015/05-2018/05,负责决明子物质基础研究.

3 科技部重大新药创制专项,符合中药特点的安全用药风险评控关键技术(2015ZX09501004) 、2015/01-2018/12,负责淫羊藿物质基础及体内过程研究.

4 国家中医药管理局中药标准化项目,注射用血栓通标准化建设(ZYBLH-C-9X-09) 、 2016/01-2018/12,负责注射用血栓通不良反应物质基础发现研究.

5 脂肝清物质基础研究, 华润三九企业横向课题, 负责何首乌药材质量分析及体内过程研究.

6 培元通脑胶囊安全性研究,河南羚锐制药股份有限公司横向课题,负责培元通脑胶囊质量 控制及安全性评价研究. 发表论文: 近5年发表 SCI 论文近

40 余篇,其中第一作者及通讯作者

12 篇,代表论文如下: 1. Mangmang Sang, Lifeng Han?, et, al. Modeling and optimizing inhibitory activities of Nelumbinis foliumextract on xanthine oxidase using response surface methodology. J. Pharm. Biomed. Anal. 2017, 139: 37C43. 2. Linlin Wang, Lifeng Han?, et, al. Rapid profiling and pharmacokinetic studies of major compounds in crude extract from Polygonum multiflorum by UHPLC-Q-TOF-MS and UPLC-MS/MS. J. Pharm. Biomed. Anal. 2017, dx.doi.org/10.1016/j.jpba.2017.03.016. 3. Mavis Boakye-Yiadom#, Lifeng Han#, Wei Li, Yi Zhang, Erwei Liu, Xinbo Song, Tao Wang*, Chemical Constituents from Stems of Cistanches deserticola,Chinese Herbal Medicines,2016. 8(3): 293-296. 4. LinLin Wang#, LiFeng Han#, HeShui Yu, MangMang Sang, Er-Wei Liu, Yi Zhang, ShiMing Fang, Tao Wang, Xiu-Mei Gao*. Analysis of the Constituents in "Zhu She Yong Xue Shuan Tong" by Ultra High Performance Liquid Chromatography with Quadrupole Time-of-Flight Mass Spectrometry Combined with Preparative High Performance Liquid Chromatography. Molecules. 2015, 20: 20518C20537. 5. Lifeng Han, Pingping Shi, Yongzhe Dong, Tingting Wang, Xiaoxia Li, Jian Hao, Yi Zhang?, Tao Wang?. New Rare Sinapoyl Acylated Flavonoid Glycosides Obtained from the Seeds of Lepidium apetalum Willd. Molecules, 2015, 20: 13982C13996. 6. Lifeng Han#, Fang Zheng#, Yi Zhang, Erwei Liu, Wei Li, Minghui Xia, Tao Wang, Xiumei Gao*. Triglyceride accumulation inhibitory effects of new chromone glycosides from Drynaria fortunei. Natural Product Research, 2015, 29, (18): 1703C1710. 7. Lifeng Han, Erwei Liu, Agyemang Kojo, Jing Zhao, Wei Li, Yi Zhang, TaoWang, Xiumei Gao. Qualitative and Quantitative Analysis of Eclipta prostrata L. by LC/MS. The Scientific World Journal, 2014, Article ID 980890. 8. Lifeng Han, Mavis Boakye-Yiadom, Yi Zhang, Peng Zhang, Erwei Liu, Tao Wang, Xiumei Gao?. Separation and purification of two isomeric saponins from albiziae cortex by high-speed counter-current chromatography and preparative high-performance liquid chromatography. Separation Science and Technology, 2014, 49: 594C600. 9. Lifeng Han, Kaunda Joseph Sakah, Lili Liu, Agyemang Kojo, Tao Wang Yi Zhang*. Saponins from Roots of Panax notoginseng. Chinese Herbal Medicines, 2014, 6(2): 159C163. 10. Han Lifeng, Zhao Jing, Zhang Yi, Kojo Agyemang, Liu Erwei, and Wang Tao?. Chemical Constituents from Dried Aerial Parts of Eclipta prostrata. Chinese Herbal Medicine, 2013, 5(4): 313C316. 11. Lifeng Han, Lina Ji, Mavis Boakye-Yiadom, Wei Li, Xinbo Song and Xiumei Gao*. Preparative Isolation and Purification of Four Compounds from Cistanches deserticola Y.C. Ma by High-Speed Counter-Current Chromatography. Molecules, 2012, 17: 8276C8284. 12. Lifeng Han#, Mavis Boakye-Yiadom#, Erwei Liu, Yi Zhang, Wei Li, Xinbo Song, Fenghua Fu and Xiumei Gao?. Structural characterization and identification of phenylethanoid glycosides from Cistanches deserticola Y.C. Ma by UHPLC/ESI-Q-TOF-MS/MS. Phytochem anal, 2012, 23: 668C676. 13. Lifeng Han, Guixiang Pan, Yuefei Wang, Xinbo Song, Xiumei Gao?,Baiping Ma, Liping Kang. Rapid profiling and identification of triterpenoid saponins in crude extracts from Albizia julibrissin Durazz. by ultra high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. J. Pharm. Biomed. Anal. 2011, 55: 996C1009. 14. Lifeng Han, Bin Wu, Guixiang Pan, Yuefei Wang, Xinbo Song, Xiumei Gao*. UPLC-PAD Analysis for Simultaneous Quantification of Four Active Compounds in Crude and Processed Rhizome of Polygonum multiflorum Thunb. Chromatographia. 2009, 70: 657-659. 15. Lifeng Han, Baiping Ma, Hongsheng Zhang, Xinbo Song?, Xiumei Gao, Liping Kang, Chengqi Xiong, Yang Zhao, Dawei Tan. 1H and 13C NMR assignments for four triterpenoid saponins from Albizziae cortex. Magn. Reson. Chem. 2008, 46: 1059-1065. 授权专利即获奖情况: 获得授权发明专利