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17 Acta Physiologica Sinica, February 25, 2008, 60(1): 17-22 http://www.

actaps.com.cn Research Paper Received 2007-08-06 Accepted 2007-09-03 This work was supported by the Program for New Century Excellent Talents in University, Ministry of Education, China (No. NCET-07-0252). * Corresponding author. Tel: +86-311-86266407;

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E-mail: [email protected] Ginkgolide B inhibits carotid sinusbaroreflex in anesthetized male rats WANG Chun-Yan, WU Yu-Ming* , XIAO Lin, XUE Hong-Mei, WANG Ru, WANG Fu-Wei, HE Rui-Rong Department of Physiology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, China Abstract: The effects of ginkgolide B on the carotid sinus baroreflex (CSB) were studied in the perfused isolated carotid sinus of

30 anesthetized Sprague-Dawley male rats. The results were as follows. (1) By perfusing with ginkgolide B (0.1, 1,

10 ?mol/L), the functional curve of the baroreflex was shifted to the right and upward. There was a marked decrease in peak slope (PS) and reflex decrease (RD) in mean arterial pressure (P