PDF《DISPATCHES》

2 d after experimental infection. In

2 of the trials, PPRV transmission was documented from pigs to

1 goat and

1 pig (trial 1) and from goats to

2 pigs (trial 3). Infectious PPRV excretion was detected in >

1 animal of each species, and PPRV RNA and seroconversion were detected in all experimentally infected or contact-infected animals (further details in online Technical Appendix Figure 1, https://wwwnc.cdc.gov/EID/article/24/12/18-0507-Techapp1.pdf). For trial 4, a 1-to-1 (pairwise) study design was chosen to estimate the reproductive ratio. The results of the sheep trial are presented in this study to enable comprehensive comparison with the PPRV pathogenesis in suids. ?One of

3 pigs was probably not infected by experimental intranasal PPRV inoculation but by contact infection. §One contact goat was infected by pigs;

however the source of infection (goat or pig) cannot be determined for the second contact goat. ?In each of

5 stables,

2 sheep were kept together:

1 experimentally infected sheep and

1 contact control sheep. Figure 1. Progression of virologic, serologic, and clinical parameters analyzed in pigs (A), wild boar (B), goats (C), and sheep (D) in Germany after experimental infection with PPRV lineage IV strain Kurdistan/2011. Results are shown for reverse transcription quantitative PCR (solid black lines), endpoint dilution as........