PDF《Psychiatry》

The link between long noncoding RNAs and depression Xiao Huang a , Yan-li Luo b , Yue-shi Mao c, ?,1 , Jian-lin Ji a, ?,1 a Department of Psychological Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China b Department of Psychiatry, Tongji Hospital of Tongji University, Shanghai 200065, China c Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China a b s t r a c t a r t i c l e i n f o Article history: Received

28 December

2015 Received in revised form

7 June

2016 Accepted

13 June

2016 Available online xxxx The major depressive disorder (MDD) is a relatively common mental disorder from which that hundreds of mil- lion people have suffered, leading to displeasing life quality, which is characterized by health damage and even suicidal thoughts.

The complicated development and functioning of MDD is still under exploration. Long noncod- ing RNA (lncRNAs) are highly expressed in the brain, could affect neural stem cell maintenance, neurogenesis and gliogenesis, brain patterning, synaptic and stress responses, and neural plasticity. The dysregulation of certain lncRNAs induces in neurodevelopmental, neurodegenerative and neuroimmunological disorders, primary brain tumors, and psychiatric diseases. Although advances have been made, no fully satisfactory treatments for major depression are available, further investigation is requested. And recently data showed that the expression level of the majority of lncRNAs demonstrated a clear tendency of upregulation, and the certain dysregulated miRNAs and lncRNAs in the MDD have been proved to have a co-synergism mechanism, that is why we speculate lncRNA might get the capability to regulate MDD. Few identi?ed lncRNAs have been deeply studied in detailed experiments up until now, little predictions of their function have been raised, and further researches is calling for discover their signal pathway and related regulatory networks. ?

2016 Elsevier Inc. All rights reserved. Keywords: Long noncoding RNAs (lncRNAs) Major depressive disorder (MDD) Mechanism Signaling pathway Biomarker Contents 1. Introduction

0 2. LncRNAs play an important role in neuropsychiatric diseases

0 3. The risk factors of depression

0 4. LncRNA expression in MDD

0 5. LncRNAs related to cognitive function potentially contribute to MDD

0 6. LncRNAs related to synaptic plasticity potentially associated with MDD

0 7. LncRNAs associated with other psychiatry diseases may also contribute to MDD

0 8. Conclusion

0 References

0 1. Introduction Depression is a comparatively common mental disorder, character- ized by enduring sadness, anhedonia, feelings of guilt or low self- worth, disturbed sleep or appetite, feelings of tiredness, and poor concentration and even suicidal thoughts (Ansorge et al., 2007;

Rao et al., 2015). Up to 2012, more than

350 million people suffer from depression all over the world, patients suffering from major depressive disorder (MDD) will get a 12-month prevalence of 6.6% and a lifetime prevalence of 16.2%, and women are twice susceptible compared to men (Thomson et al., 2014). Compared to unipolar depression patients, bipolar patients are much more likely to present to clinicians, while uni- polar depression is more prevalent than bipolar disorder (Hirschfeld, 2014). The clinical presentation of patients with unipolar depression is more likely to show typical depressive symptoms including sad mood, anxiety, insomnia, and somatic depressive symptoms. However the clinical presentation of patients with bipolar disorder, are more likely to show inverse neuro-vegetative symptoms, particularly hypersomnia, increased appetite and weight gain (Hirschfeld, 2014). Progress in Neuro-Psychopharmacology &