PDF《Psychiatry》

Biological Psychiatry xxx (2016) xxxCxxx ? Corresponding authors at: Zhongshan Hospital, Fudan University,

180 Fenglin Road, Shanghai 200032, China. E-mail address: [email protected] (J. Ji).

1 The authors contributed equally to this work. They are co-corresponding author. PNP-08932;

No of Pages

6 http://dx.doi.org/10.1016/j.pnpbp.2016.06.004 0278-5846/?

2016 Elsevier Inc. All rights reserved. Contents lists available at ScienceDirect Progress in Neuro-Psychopharmacology &

Biological Psychiatry journal homepage: www.elsevier.com/locate/pnp Please cite this article as: Huang, X., et al., The link between long noncoding RNAs and depression, Prog Neuro-Psychopharmacol Biol Psychiatry (2016), http://dx.doi.org/10.1016/j.pnpbp.2016.06.004 Current antidepressants, such as serotonin (5-HT) re-uptake inhibitors (SSRIs) were commonly applied in treating depression (Hetrick et al., 2007;

Chaplin and Krishnadas, 2014). Recent years, advances have been made in improving the diagnosis and treatment of MDD patients, for example, many promising biomarkers have been intensively investi- gated for the early diagnosis of MDD and as treatment targets for novel drug development (Redei and Mehta, 2015). Despite these, many efforts still needed in future studies. Though only less than 1% of the mammalian genome that are tran- scribed into mRNA, the major part of the genome is non-coding RNAs (ncRNA) what was previously considered as transcriptional noise , that do not encode information about proteins (Ma et al., 2015;

Mckiernan and Greene, 2015). Long non-coding RNAs (lncRNAs) are those over

200 nucleotides in length and do not have a functional open reading frame (ORF) (Ma et al., 2013;

Esteller, 2011). LncRNAs have multiple functions including the ability to regulate transcription/ gene expression by recruitment of transcription factors, modulate mRNA processing, adjust post-transcriptional pathways (like transla- tion, miRNA sponges and mRNA stability), DNA methylation and scaffold to organize and hold higher-order complexes, modulate chro- matin structure by recruitment of histone and chromatin modi?ers to speci?c genomic loci and so on (Salmena et al., 2011;

Wang and Chang, 2011;

Geisler and Coller, 2013). Thus, lncRNAs may play some roles in disease pathologic process, and intense investigations have been implemented to ?nd new molecules and mechanisms of complex diseases, providing light on the potential of u........