PDF《Int Eye Sci, Vol. 15 , No. 11 ,》

・临床报告・ 应用 3D OCT 测量中老年人正常眼视网膜神经纤维层 厚度 李摇 莉,李摇 敏,曾思明,陈丽妃 作者单位:(530021)中国广西壮族自治区南宁市,广西壮族自治 区人民医院眼科 作者简介:李莉,女,广西医科大学在读硕士研究生,住院医师, 研究方向:眼底病.

通讯作者:李敏,毕业于广西医科大学,医学硕士,主任医师,科 主任,研究方向:眼底病. limin00899@ 163. com 收稿日期: 2015-08-19 摇摇修回日期: 2015-10-22 Retinal nerve fiber layer thickness of middle aged or elderly people measured by 3D optical coherence tomography Li Li, Min Li, Si-Ming Zeng, Li-Fei Chen Department of Ophthalmology, the People蒺s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi Zhuang Autonomous Region, China Correspondence to: Min Li. Department of Ophthalmology, the People蒺s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021,Guangxi Zhuang Autonomous Region, China. limin00899@ 163. com Received:2015-08-19摇摇Accepted:2015-10-22 Abstract SAIM: To build the reference values of normal eye retinal nerve fiber layer (RNFL) thickness on middle aged people between

40 ~

69 years old, and infer the baseline data for early diagnosis of glaucoma. SMETHODS:A total of

180 eyes from

90 healthy subjects (age ranged from

40 ~

69 years old) were recruited for this study. Topcon 3D optical coherence tomography (OCT) -

2000 (Ver 8. 0)was used to measure RNFL thickness. Each subject was performed circular scans around the optic nerve with a circle size of 3. 4mm. Clock-hour, quadrant and total average RNFL thicknesses were recorded. The data was analyzed with SPSS statistical. The relationship between age, gender and laterality was analyzed, and the reference value for normal eye RNFL thickness parameters was obtained, SRESULTS: Normal RNFL thickness distribution was bimodal curve type in

40 ~

69 year - old middle aged or elderly people. RNFL thickness was decreased for temporal quadrant, followed by nasal, superior, inferior. RNFL thickness at

10 o蒺clock,

5 o蒺clock,

6 o蒺clock, superior got thinner with age prolong. Except

10 o蒺clock (P0. 05). The RNFL thickness at

11 o蒺clock was associated with different gender. the RNFL thickness at

11 o蒺clock,

12 o蒺clock,

1 o蒺clock,

4 o蒺clock, superior, nasal was associated with different eyes, the differences was statistically significant between different eyes (P上方>鼻侧>颞侧;

10颐00 位、5颐00 位、6颐00 位、 上方 RNFL 厚度随年龄增长而变薄,10颐00 位差异有统计 学意义( P0.

05 ) ;

除11颐00 位外,其余 RNFL 厚度与性别无关;

11 颐00 位、 12颐00 位、1颐00 位、4颐00 位、上方及鼻侧 RNFL 厚度与眼别 有关,差异有统计学意义(P上方>鼻侧>颞侧,与ISNT 原则符合. 赵 桂玲等[3] 测量

110 例青年人的 3D OCT RNFL,结果显示上 方RNFL 厚度为 126. 12依18. 57滋m[3] ,颞侧 RNFL 厚度为 89.

88 依14. 09滋m[3] , 下方RNFL 厚度为132.

33 依16郾87滋m[3] ,鼻侧 RNFL 厚度为 65. 70依13. 62滋m[3] . 本研 究结论与赵桂玲等研究结果相一致,也与 Mansoori 等[4] 和Budenz 等[5] 研究的结果相吻合. 摇摇目前普遍认为年龄是影响 RNFL 厚度的一个重要因 素. 本研究将 A 组、B 组、C 组年龄段间进行比较,发现除 10颐00 位A组与 B 组、A 组与 C 组间差异有统计学意义(P 0. 05). 马晓昀等[6] 对1002Int Eye Sci, Vol. 15, No. 11, Nov. 2015摇摇http:/ / ies. ijo. cn Tel:029鄄82245172摇82210956摇摇Email:IJO. 2000@163. com